Document Detail


HLA antigen sharing between mother and fetus as a risk factor for eclampsia and preeclampsia.
MedLine Citation:
PMID:  20074602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immune maladaption between mother and infant has been suggested to induce preeclampsia/eclampsia. When fetuses share more human leukocyte antigen (HLA) types with their mother, immune differences would be limited and thereby could affect this risk. Data from Danish women (1996-2002) with single live-birth pregnancies complicated by severe preeclampsia/eclampsia were compared to women with term pregnancies uncomplicated by hypertension. HLA A, B, and DR types were resolved at the intermediate-level typing (antigen). A total of 201 cases and 195 control mother-infant pairs had complete HLA types. The odds ratios of preeclampsia/eclampsia in mothers sharing both HLA antigens with their infants were 1.19 (95% confidence interval: 0.81-1.76) for HLA A, 0.91 (0.59-1.42) for HLA B, and 1.05 (0.5-1.59) for HLA DR antigens. No specific HLA antigens in either mother or infant appeared important after Bonferroni correction, except possibly DR01 in mothers (protective). Thus, maladaption mediated by adaptive immunity between mother and infant is not the basis for the mother developing preeclampsia/eclampsia.
Authors:
Robert J Biggar; Gry Poulsen; Jennifer Ng; Mads Melbye; Heather A Boyd
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-25
Journal Detail:
Title:  Human immunology     Volume:  71     ISSN:  1879-1166     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-09-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-7     Citation Subset:  IM    
Copyright Information:
(c) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. rjbiggar@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Denmark
Eclampsia / epidemiology,  genetics*,  metabolism
Female
Fetus
Genetic Association Studies
HLA Antigens / genetics*,  metabolism
Histocompatibility / genetics
Histocompatibility Testing
Humans
Maternal-Fetal Exchange / immunology*
Pre-Eclampsia / epidemiology,  genetics*,  metabolism
Pregnancy
Prospective Studies
Registries
Risk Factors
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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