Document Detail


HLA antigen and antibody association in platelet-alloimmunized patients.
MedLine Citation:
PMID:  8334558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequencies of HLA antigens were compared between 55 patients with and 38 patients without lymphocytotoxic antibodies formation after long-term platelet transfusions. Only HLA-B60 and B75 were found to manifest significant difference between these two groups. Patients with HLA homozygosity had a higher incidence of alloimmunization. Although most of the platelet alloantibodies were against HLA antigens of high frequency, the HLA-antibodies were induced at a rate different from the frequency of their corresponding antigens. The antibodies against the first and second HLA loci are of similar frequencies. In conclusion, the patients with HLA homozygous alleles have a higher incidence of platelet alloimmunization, and the antibody of certain specificities has higher rate of occurrence. These findings may be helpful in platelet-donor selection.
Authors:
M P Chow; J S Lin; C K Lin; B I Kuo; C H Yung; J Y Lyou; H Y Hu; J L Tzeng; T D Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zhonghua yi xue za zhi = Chinese medical journal; Free China ed     Volume:  51     ISSN:  0578-1337     ISO Abbreviation:  Zhonghua Yi Xue Za Zhi (Taipei)     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-08-24     Completed Date:  1993-08-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0005327     Medline TA:  Zhonghua Yi Xue Za Zhi (Taipei)     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  329-32     Citation Subset:  IM    
Affiliation:
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
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MeSH Terms
Descriptor/Qualifier:
Antibody Specificity
Antilymphocyte Serum / blood*
Blood Component Transfusion*
Blood Platelets / immunology*
HLA Antigens / analysis*,  genetics,  immunology
Homozygote
Humans
Immunization
Isoantibodies / blood*
Chemical
Reg. No./Substance:
0/Antilymphocyte Serum; 0/HLA Antigens; 0/Isoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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