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HLA-Mismatched Stem-Cell Microtransplantation As Postremission Therapy for Acute Myeloid Leukemia: Long-Term Follow-Up.
MedLine Citation:
PMID:  23045576     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSEDespite best current therapies, approximately half of patients with acute myeloid leukemia in first complete remission (AML-CR1) with no HLA-identical donors experience relapse. Whether HLA-mismatched stem-cell microtransplantation as a novel postremission therapy in these patients will improve survival and avoid graft-versus-host disease (GVHD) is still unknown. PATIENTS AND METHODSOne hundred one patients with AML-CR1 (9 to 65 years old) from four treatment centers received programmed infusions of G-CSF-mobilized HLA-mismatched donor peripheral-blood stem cells after each of three cycles of high-dose cytarabine conditioning without GVHD prophylaxis. Donor chimerism and microchimerism and WT1(+)CD8(+) T cells were analyzed. RESULTS: 01 antigen by a pentamer analysis. CONCLUSIONMicrotransplantation as a postremission therapy may improve outcomes and avoid GVHD in patients with AML-CR1.
Authors:
Mei Guo; Kai-Xun Hu; Guang-Xian Liu; Chang-Lin Yu; Jian-Hui Qiao; Qi-Yun Sun; Jun-Xiao Qiao; Zheng Dong; Wan-Jun Sun; Xue-Dong Sun; Hong-Li Zuo; Qiu-Hong Man; Zhi-Qing Liu; Tie-Qiang Liu; Hong-Xia Zhao; Ya-Jing Huang; Li Wei; Bing Liu; Juan Wang; Xu-Liang Shen; Hui-Sheng Ai
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  -     ISSN:  1527-7755     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Mei Guo, Kai-Xun Hu, Guang-Xian Liu, Chang-Lin Yu, Jian-Hui Qiao, Qi-Yun Sun, Zheng Dong, Xue-Dong Sun, Hong-Li Zuo, Qiu-Hong Man, Zhi-Qing Liu, Tie-Qiang Liu, Li Wei, Bing Liu, and Hui-Sheng Ai, Affiliated Hospital of Academy of Military Medical Sciences; Jun-Xiao Qiao, Wan-Jun Sun, Hong-Xia Zhao, and Ya-Jing Huang, Second Artillery General Hospital, Beijing; Juan Wang, Centre Hospital of Cangzhou City, Cangzhou; and Xu-Liang Shen, Chang Zhi Medical College, Chang Zhi, China.
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