Document Detail

HLA and Japanese MS.
MedLine Citation:
PMID:  80838     Owner:  NLM     Status:  MEDLINE    
Determination of HLA-A, -B and -C types in 43 Japanese patients with multiple sclerosis (MS) and of DR type in 25 MS patients was carried out using antisera from the 7th International Histocompatibility Workshop. The results were compared with 46 controls typed simultaneously. Twenty-three patients were also tested for HLA-Dw2. The conclusions were: 1) There were no significantly higher occurrences of HLA-A3, B7, Dw2 or DRw2 in Japanese MS. 2) Japanese MS might nevertheless be associated with the human major histocompatibility complex, because HLA-B40 was significantly less frequent in MS and two anti HLA-DRw sera, 7w008 and 034, reacted positively more often against lymphocytes from MS patients.
S Naito; Y Kuroiwa; T Itoyama; T Tsubaki; A Horikawa; T Sasazuki; S Noguchi; S Ohtsuki; H Tokuomi; T Miyatake; N Takahata; S Kawanami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  12     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-11-22     Completed Date:  1978-11-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
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MeSH Terms
Gene Frequency
HLA Antigens* / analysis
Lymphocytes / immunology
Major Histocompatibility Complex
Multiple Sclerosis / genetics*
Reg. No./Substance:
0/Epitopes; 0/HLA Antigens

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