Document Detail


HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq.
MedLine Citation:
PMID:  22651916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HLA-G is a nonclassical, class I major histocompatibility complex (MHC) gene that exhibits immunomodulatory properties and likely plays a role in the maintenance of successful pregnancy. In this study, we investigated the role of HLA-G polymorphisms on risk for recurrent pregnancy loss (RPL) and on circulating levels of soluble (s)HLA-G in Iraqi women. DNA and plasma were obtained from blood samples collected at 9-12 weeks gestation from 50 women with RPL and 50 healthy pregnant women in Basrah province, Iraq. As measured by ELISA, median sHLA-G levels were significantly lower in the RPL cases compared to healthy controls (21.4 vs. 38.8 U/ml, respectively; P=0.025), and decreased with increasing maternal age (P=0.0051). However, HLA-G allele and haplotype frequencies did not differ significantly between cases and controls (P values ≥0.12 for all tests). In contrast, homozygosity for the C allele (CC) at a tri-allelic promoter polymorphism, -725C/G/T, was associated with lower concentrations of sHLA-G compared to the CG or CT genotypes (median levels 21.1 vs. 40.1 vs. 42.6 U/ml, respectively; P=0.0089). These results demonstrate that HLA-G genotype influences circulating sHLA-G levels during pregnancy but is not significantly associated with risk of RPL.
Authors:
Raghed M Jassem; Wafaa Sadoon Shani; Dagan A Loisel; Maysoon Sharief; Christine Billstrand; Carole Ober
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-28
Journal Detail:
Title:  Human immunology     Volume:  73     ISSN:  1879-1166     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2013-01-21     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  811-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Affiliation:
Basic Science Department, Dentistry College, University of Basrah, Basrah, Iraq.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / genetics*,  immunology
Adult
Alleles
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Gene Frequency
Genotype
HLA-G Antigens / genetics*,  immunology
Haplotypes
Humans
Iraq
Maternal Age
Polymorphism, Genetic*
Pregnancy
Pregnancy Trimester, First
Risk Factors
Solubility
Grant Support
ID/Acronym/Agency:
F32 HL095268/HL/NHLBI NIH HHS; P01 HD049480/HD/NICHD NIH HHS; P01 HD049480/HD/NICHD NIH HHS; T32 HL007605/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/HLA-G Antigens
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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