| HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq. | |
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MedLine Citation:
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PMID: 22651916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HLA-G is a nonclassical, class I major histocompatibility complex (MHC) gene that exhibits immunomodulatory properties and likely plays a role in the maintenance of successful pregnancy. In this study, we investigated the role of HLA-G polymorphisms on risk for recurrent pregnancy loss (RPL) and on circulating levels of soluble (s)HLA-G in Iraqi women. DNA and plasma were obtained from blood samples collected at 9-12 weeks gestation from 50 women with RPL and 50 healthy pregnant women in Basrah province, Iraq. As measured by ELISA, median sHLA-G levels were significantly lower in the RPL cases compared to healthy controls (21.4 vs. 38.8 U/ml, respectively; P=0.025), and decreased with increasing maternal age (P=0.0051). However, HLA-G allele and haplotype frequencies did not differ significantly between cases and controls (P values ≥0.12 for all tests). In contrast, homozygosity for the C allele (CC) at a tri-allelic promoter polymorphism, -725C/G/T, was associated with lower concentrations of sHLA-G compared to the CG or CT genotypes (median levels 21.1 vs. 40.1 vs. 42.6 U/ml, respectively; P=0.0089). These results demonstrate that HLA-G genotype influences circulating sHLA-G levels during pregnancy but is not significantly associated with risk of RPL. |
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Authors:
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Raghed M Jassem; Wafaa Sadoon Shani; Dagan A Loisel; Maysoon Sharief; Christine Billstrand; Carole Ober |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-05-28 |
Journal Detail:
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Title: Human immunology Volume: 73 ISSN: 1879-1166 ISO Abbreviation: Hum. Immunol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-23 Completed Date: 2013-01-21 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 811-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Basic Science Department, Dentistry College, University of Basrah, Basrah, Iraq. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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genetics*,
immunology Adult Alleles Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Gene Frequency Genotype HLA-G Antigens / genetics*, immunology Haplotypes Humans Iraq Maternal Age Polymorphism, Genetic* Pregnancy Pregnancy Trimester, First Risk Factors Solubility |
| Grant Support | |
ID/Acronym/Agency:
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F32 HL095268/HL/NHLBI NIH HHS; P01 HD049480/HD/NICHD NIH HHS; P01 HD049480/HD/NICHD NIH HHS; T32 HL007605/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA-G Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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