Document Detail


HLA-G gene polymorphism in human placentas: possible association of G*0106 allele with preeclampsia and miscarriage.
MedLine Citation:
PMID:  18509163     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Definite causes for several pathologies of pregnancy remain unknown. In light of several recent studies, however, diminished or aberrant HLA-G expression may be associated with certain complication of pregnancy and be linked to HLA-G polymorphism. We analyzed DNA from 60 normal placentas (controls), 140 placentas from miscarriage, 36 placentas from preeclampsia, 76 placentas from fetal hypotrophy, and 34 placentas with hypoxia for variations in coding regions (allelic groups G*0101 to G*0107) and the 14-bp deletion/insertion into the 3'-untranslated region. No statistically significant differences were observed in the distribution of allelic group between pathological placentas and controls with the exception of G*0106 allele frequency in preeclamptic compared with control placentas (21.2% and 6.6%, respectively). A greater frequency of this allele also was observed in the two subgroups of miscarriage and hypoxia compared with that in controls. In addition, presence of the 14-bp sequence was prominent in preeclampsia compared with controls (60.8% vs. 35%, respectively), and homozygotes with deletion were not detected in the pathology. The results suggest that the G*0106 allele, which is coupled with the presence of the 14-bp sequence, contributes and/or is a relevant marker in some specific complications of pregnancy, especially preeclampsia.
Authors:
Philippe Moreau; Licinio Contu; Francesco Alba; Sara Lai; Renata Simoes; Sandro Orrù; Carlo Carcassi; Michel Roger; Michèle Rabreau; Edgardo D Carosella
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Publication Detail:
Type:  Journal Article     Date:  2008-05-28
Journal Detail:
Title:  Biology of reproduction     Volume:  79     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  459-67     Citation Subset:  IM    
Affiliation:
Commissariat à l'Energie Atomique, IBM, Service de Recherches en Hémato-Immunologie, IUH, Hôpital Saint-Louis, 75475 Paris, France. philippe.moreau@cea.fr
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions / genetics
Abortion, Spontaneous / genetics*,  metabolism,  pathology
Adolescent
Adult
Alleles
Biological Markers / metabolism
Female
Gene Frequency
Genetic Predisposition to Disease
HLA Antigens / genetics*,  metabolism,  physiology
Histocompatibility Antigens Class I / genetics*,  metabolism
Humans
Linkage (Genetics)
Placenta / metabolism*,  pathology
Polymorphism, Genetic*
Pre-Eclampsia / genetics*,  metabolism,  pathology
Pregnancy
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/Biological Markers; 0/HLA Antigens; 0/HLA-G antigen; 0/HLA-G*0106; 0/Histocompatibility Antigens Class I

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