| HLA-G gene polymorphism in human placentas: possible association of G*0106 allele with preeclampsia and miscarriage. | |
| | |
MedLine Citation:
|
PMID: 18509163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Definite causes for several pathologies of pregnancy remain unknown. In light of several recent studies, however, diminished or aberrant HLA-G expression may be associated with certain complication of pregnancy and be linked to HLA-G polymorphism. We analyzed DNA from 60 normal placentas (controls), 140 placentas from miscarriage, 36 placentas from preeclampsia, 76 placentas from fetal hypotrophy, and 34 placentas with hypoxia for variations in coding regions (allelic groups G*0101 to G*0107) and the 14-bp deletion/insertion into the 3'-untranslated region. No statistically significant differences were observed in the distribution of allelic group between pathological placentas and controls with the exception of G*0106 allele frequency in preeclamptic compared with control placentas (21.2% and 6.6%, respectively). A greater frequency of this allele also was observed in the two subgroups of miscarriage and hypoxia compared with that in controls. In addition, presence of the 14-bp sequence was prominent in preeclampsia compared with controls (60.8% vs. 35%, respectively), and homozygotes with deletion were not detected in the pathology. The results suggest that the G*0106 allele, which is coupled with the presence of the 14-bp sequence, contributes and/or is a relevant marker in some specific complications of pregnancy, especially preeclampsia. |
| | |
Authors:
|
Philippe Moreau; Licinio Contu; Francesco Alba; Sara Lai; Renata Simoes; Sandro Orrù; Carlo Carcassi; Michel Roger; Michèle Rabreau; Edgardo D Carosella |
Related Documents
:
|
12620933 - Temporal regulation of the expression of syncytin (herv-w), maternally imprinted peg10,... 17568663 - Placentation in cloned cattle: structure and microvascular architecture. 18634013 - Prevention of ntds with periconceptional multivitamin supplementation containing folic ... |
Publication Detail:
|
Type: Journal Article Date: 2008-05-28 |
Journal Detail:
|
Title: Biology of reproduction Volume: 79 ISSN: 0006-3363 ISO Abbreviation: Biol. Reprod. Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-08-25 Completed Date: 2008-11-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: United States |
Other Details:
|
Languages: eng Pagination: 459-67 Citation Subset: IM |
Affiliation:
|
Commissariat à l'Energie Atomique, IBM, Service de Recherches en Hémato-Immunologie, IUH, Hôpital Saint-Louis, 75475 Paris, France. philippe.moreau@cea.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3' Untranslated Regions
/
genetics Abortion, Spontaneous / genetics*, metabolism, pathology Adolescent Adult Alleles Biological Markers / metabolism Female Gene Frequency Genetic Predisposition to Disease HLA Antigens / genetics*, metabolism, physiology Histocompatibility Antigens Class I / genetics*, metabolism Humans Linkage (Genetics) Placenta / metabolism*, pathology Polymorphism, Genetic* Pre-Eclampsia / genetics*, metabolism, pathology Pregnancy |
| Chemical | |
Reg. No./Substance:
|
0/3' Untranslated Regions; 0/Biological Markers; 0/HLA Antigens; 0/HLA-G antigen; 0/HLA-G*0106; 0/Histocompatibility Antigens Class I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast gr...
Next Document: Cleavage of disulfide bonds in mouse spermatogenic cell-specific type 1 hexokinase isozyme is associ...