| HLA-G: from biology to clinical benefits. | |
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MedLine Citation:
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PMID: 18249584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relevance of the nonclassical human leukocyte antigen (HLA) class I molecule HLA-G in human physiological and pathological contexts has been the center of intense investigation. In light of the recent advances, we report here the clinical implications of HLA-G as a tolerogenic molecule promoting uterine implantation of the embryo or acceptance of solid allografts while allowing the evasion of tumors or viruses from the immune response. These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels. |
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Authors:
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Edgardo D Carosella; Philippe Moreau; Joël Lemaoult; Nathalie Rouas-Freiss |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-02-04 |
Journal Detail:
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Title: Trends in immunology Volume: 29 ISSN: 1471-4906 ISO Abbreviation: Trends Immunol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-05 Completed Date: 2008-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 125-32 Citation Subset: IM |
Affiliation:
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Institut Universitaire d'Hématologie, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, IUH, 1 75010 Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryo Implantation / immunology HLA Antigens / physiology*, therapeutic use* Histocompatibility Antigens Class I / physiology*, therapeutic use* Humans Transplantation Tolerance / immunology Tumor Escape / immunology |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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