Document Detail

HLA-G expression in trophoblast cells is independent of embryonic development.
MedLine Citation:
PMID:  11137214     Owner:  NLM     Status:  MEDLINE    
HLA-G is a nonclassical major histocompatibility complex class I molecule that is selectively expressed on cytotrophoblasts at the feto-maternal interface where it may play a major role in maternal-fetal tolerance. In this study, we compared HLA-G expression in trophoblasts from normal and pathologic pregnancies by immunohistochemical analysis. First, we found a defective HLA-G expression in miscarriages associated with hypotrophic but normal eggs. Conversely, by studying molar pregnancies, we observed a high HLA-G expression in complete and partial hydatidiform moles. Finally, HLA-G expression could be visualized in extravillous trophoblasts that develop outside of their normal environment, as reported here in ectopic pregnancies. Taken together, these results suggest that HLA-G expression in extravillous trophoblasts is induced in an autonomous manner, independently of embryonic development, and may be an integral part of placental development allowing its tolerance from maternal immune system.
M Rabreau; N Rouas-Freiss; M Landi; C Le Danff; E D Carosella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human immunology     Volume:  61     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-16     Completed Date:  2001-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1108-12     Citation Subset:  IM    
Institut d'Histo-Cyto-Pathologie, Le Bouscat, France.
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MeSH Terms
Abortion, Spontaneous / immunology
Fallopian Tubes / pathology
HLA Antigens / immunology*
Histocompatibility Antigens Class I / immunology*
Hydatidiform Mole / immunology
Pregnancy Complications / immunology*
Pregnancy, Ectopic / immunology
Trophoblasts / immunology*
Reg. No./Substance:
0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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