Document Detail


HLA-G expression in trophoblast cells is independent of embryonic development.
MedLine Citation:
PMID:  11137214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HLA-G is a nonclassical major histocompatibility complex class I molecule that is selectively expressed on cytotrophoblasts at the feto-maternal interface where it may play a major role in maternal-fetal tolerance. In this study, we compared HLA-G expression in trophoblasts from normal and pathologic pregnancies by immunohistochemical analysis. First, we found a defective HLA-G expression in miscarriages associated with hypotrophic but normal eggs. Conversely, by studying molar pregnancies, we observed a high HLA-G expression in complete and partial hydatidiform moles. Finally, HLA-G expression could be visualized in extravillous trophoblasts that develop outside of their normal environment, as reported here in ectopic pregnancies. Taken together, these results suggest that HLA-G expression in extravillous trophoblasts is induced in an autonomous manner, independently of embryonic development, and may be an integral part of placental development allowing its tolerance from maternal immune system.
Authors:
M Rabreau; N Rouas-Freiss; M Landi; C Le Danff; E D Carosella
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human immunology     Volume:  61     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-01-16     Completed Date:  2001-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1108-12     Citation Subset:  IM    
Affiliation:
Institut d'Histo-Cyto-Pathologie, Le Bouscat, France. ihcp@wanadoo.fr
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / immunology
Fallopian Tubes / pathology
Female
HLA Antigens / immunology*
Histocompatibility Antigens Class I / immunology*
Humans
Hydatidiform Mole / immunology
Immunohistochemistry
Pregnancy
Pregnancy Complications / immunology*
Pregnancy, Ectopic / immunology
Trophoblasts / immunology*
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-G antigen; 0/Histocompatibility Antigens Class I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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