Document Detail

HLA-E and immunobiology of pregnancy.
MedLine Citation:
PMID:  16573557     Owner:  NLM     Status:  MEDLINE    
Recently, it has been suggested that non-classical antigens such as human leukocyte antigen (HLA)-G and HLA-E may interact with KIR receptors of NK cells which results into downregulation of immune response and helps in the maintenance of pregnancy. In the present study, we have investigated HLA-E polymorphism in normal fertile women and recurrent spontaneous aborters to assess the effect of HLA-E alleles on the success of pregnancy. Allele E*0101 was found to be significantly higher in patients with recurrent spontaneous abortion (chi(2) = 4.097 and P = 0.0430). Differential expression, peptide affinity, and stability of E*0101 may be one of the reasons.
P Tripathi; S Naik; S Agrawal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  67     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-31     Completed Date:  2006-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradhesh, India.
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MeSH Terms
Abortion, Habitual / genetics,  immunology*
Gene Frequency
HLA Antigens / chemistry,  genetics*,  immunology
Histocompatibility Antigens Class I / chemistry,  genetics*,  immunology
Models, Molecular
Nucleic Acid Amplification Techniques
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Pregnancy Outcome
Pregnancy Trimester, First
Receptors, Immunologic / immunology,  metabolism
Receptors, KIR
Reg. No./Substance:
0/Codon; 0/HLA Antigens; 0/HLA-E antigen; 0/Histocompatibility Antigens Class I; 0/Receptors, Immunologic; 0/Receptors, KIR

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