| HLA-E and immunobiology of pregnancy. | |
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MedLine Citation:
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PMID: 16573557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, it has been suggested that non-classical antigens such as human leukocyte antigen (HLA)-G and HLA-E may interact with KIR receptors of NK cells which results into downregulation of immune response and helps in the maintenance of pregnancy. In the present study, we have investigated HLA-E polymorphism in normal fertile women and recurrent spontaneous aborters to assess the effect of HLA-E alleles on the success of pregnancy. Allele E*0101 was found to be significantly higher in patients with recurrent spontaneous abortion (chi(2) = 4.097 and P = 0.0430). Differential expression, peptide affinity, and stability of E*0101 may be one of the reasons. |
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Authors:
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P Tripathi; S Naik; S Agrawal |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Tissue antigens Volume: 67 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-31 Completed Date: 2006-05-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 207-13 Citation Subset: IM |
Affiliation:
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Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradhesh, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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genetics,
immunology* Alleles Codon Exons Female Gene Frequency HLA Antigens / chemistry, genetics*, immunology Histocompatibility Antigens Class I / chemistry, genetics*, immunology Humans Models, Molecular Mutation Nucleic Acid Amplification Techniques Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Pregnancy Pregnancy Outcome Pregnancy Trimester, First Receptors, Immunologic / immunology, metabolism Receptors, KIR |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/HLA Antigens; 0/HLA-E antigen; 0/Histocompatibility Antigens Class I; 0/Receptors, Immunologic; 0/Receptors, KIR |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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