Document Detail

HLA-Dw1 and BfF as protective markers in multiple sclerosis.
MedLine Citation:
PMID:  6558078     Owner:  NLM     Status:  MEDLINE    
The frequencies of Properdin factor B allotypes were studied in 54 multiple sclerosis patients and 58 healthy control subjects, and the association of various phenotypes with HLA-Dw1 and Dw2 antigens (found with decreased and increased frequency in MS patients, respectively) was further studied. SS genotype was found in 76% of MS patients and 63% of control subjects (n.s.) F types (FS + FF) were found to be strongly associated with HLA-Dw1 in control subjects (P less than 0.0014), whereas neither SS nor F containing types were associated with Dw2. The findings support the concept of a hypothetical MS resistance factor in the HLA gene area.
J Ilonen; A Lagerstedt; S Koskimies; M Reunanen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  5     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-02-23     Completed Date:  1984-02-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
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MeSH Terms
Complement Factor B / genetics*
Enzyme Precursors / genetics*
HLA Antigens / genetics*
Multiple Sclerosis / genetics*
Reg. No./Substance:
0/Enzyme Precursors; 0/HLA Antigens; EC Factor B

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