| HLA-DRnegative, CD34negative Hypergranular Acute Myeloid Leukemia With Trisomy 6 and del(5)(q22q33): Case Report and Review of the Literature. | |
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MedLine Citation:
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PMID: 21768886 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We report a unique pediatric case of hypergranular acute myeloid leukemia with myelodysplasia-related changes. The patient presented with moderate leukocytosis with neutrophilia with left-shift maturation and dysplasia, anemia, and multiple sclerotic bone lesions. The bone marrow was hypercellular with a predominance of myeloblast cells and/or abnormal promyelocytes with hypergranular cytoplasm. Flow cytometric immunophenotyping showed that the leukemic cells were positive for CD13, CD33, and myeloperoxidase, and negative for HLA-DR and CD34. Morphology and immunophenotyping were highly suggestive of acute promyelocytic leukemia. The classic t(15;17) or other RARα rearrangements were not detected by cytogenetic or molecular assays, ruling out acute promyelocytic leukemia. Standard cytogenetic analysis showed that the karyotype of the predominant clone was 47,XY,+6 with evidence of clonal evolution to 47,XY,+6,del(5)(q22q33). A literature and database review showed that trisomy 6 is a rare occurrence in hematological malignancies and, to our knowledge, has never been reported in association with del(5)(q22q33) in a child presenting with hypergranular acute myeloid leukemia with myelodysplasia-related changes. We present a current review of the literature and summarize the clinical features of 57 cases of trisomy 6 as the primary chromosomal abnormality in hematological disease. |
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Authors:
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Bob Argiropoulos; Brian Clifford; Susan Crocker; Elizabeth Sinclair-Bourque; Elizabeth McCready; Jean McGowan-Jordan; Donna L Johnston; Ruth Padmore |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-15 |
Journal Detail:
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Title: Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology Volume: - ISSN: 1536-3678 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Department of Genetics, Cytogenetics Laboratory ‡Division of Hematology/Oncology, Children's Hospital of Eastern Ontario †Department of Pediatrics, University of Ottawa §Division of Hematopathology and Transfusion Medicine, The Ottawa Hospital, Ottawa, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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