Document Detail

HLA-DRB1 alleles genotyping in patients with rheumatoid arthritis in Chinese.
MedLine Citation:
PMID:  9387389     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the role of HLA-DRB1 genes in the development of rheumatoid arthritis (RA) and the correlations between HLA-DR alleles and clinical manifestations of patients with RA. METHODS: 86 patients with rheumatoid arthritis and 106 race matched controls were studied in whom HLA-DR typing was performed by the method of DNA amplification with sequence-specific primers (PCR-SSP). The subtypes of HLA-DR4 were determined by the method of hybridization of PCR products with sequence-specific oligonucleotides (PCR-SSO). The absence or presence of HLA-DR4 and its subtypes was correlated with the clinical and serological characteristics of the patients. RESULTS: Compared with controls, an increased gene frequency of HLA-DR4 (48.8% vs 17.9%, P < 0.001) and a decreased frequency of HLA-DR7 (16.3% vs 27.4%, P = 0.06) were found. The DRB1* 0405 account for 61.9% of DR4+RA patients and 21.1% of DR4+ controls (P < 0.01). There was no difference between the DR4+ and DR4- patients with respect to age, sex, duration of disease, rheumatoid factor (RF), extra-articular manifestations including secondary Sjogren's syndrome. According to the wrist X-ray stage, the patients of DR4+ were more severe than that of DR4- (P < 0.05). CONCLUSION: HLA-DR4 and DR4 subtype of DRB1*0405 are related to the development of RA in Chinese. HLA-DR4 can be a useful prognostic marker in the patients with RA.
Y Zhao; Y Dong; X Zhu; C Qiu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  11     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-12-31     Completed Date:  1997-12-31     Revised Date:  2005-05-14    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  232-5     Citation Subset:  IM    
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, Beijing.
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MeSH Terms
Arthritis, Rheumatoid / genetics*,  immunology
Biological Markers / analysis
Gene Frequency
HLA-DR Antigens / metabolism*
HLA-DR4 Antigen / metabolism
Reg. No./Substance:
0/Biological Markers; 0/HLA-DR Antigens; 0/HLA-DR4 Antigen; 128338-86-3/HLA-DRB1 antigen

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