Document Detail


HLA-DRB1 and HLA-DQB1 genes and allergic broncopulmonary aspergillosis susceptibility and protection in patients with cystic fibrosis.
MedLine Citation:
PMID:  23278646     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease that affects patients with cystic fibrosis (CF) and asthmatic patients. Indeed, HLA-DRB1 alleles have previously been associated with ABPA-CF susceptibility although HLA-DQB1 allele associations were not clearly established. Our aim was to study HLA class II associations in our ABPA-CF patients and determine their role in susceptibility or protection. Patients with ABPA-CF, CF patients without ABPA, asthmatic patients without ABPA (AST) and healthy controls were included in this study. DNA was extracted by automatic extractor. HLA-DRB1 and -DQB1 genotyping was performed by luminex PCR-SSO method (OneLambda, CA). Allele specific PCR-SSP was also performed by high resolution analysis (OL, CA). Statistical analysis was performed by SSPS and Arlequin softwares. Both HLA-DRB1*15:01 and -DRB1*11:04 alleles showed an increased frequency in ABPA-CF patients with respect to AST, CF and controls, corroborating the data previously published. On the other hand, analysis of haplotypes revealed that almost all patients with ABPA-CF lacking DRB1*15:01 or DRB1*11:04 carry either DRB1*04, DRB1*11:01 or DRB1*07:01 alleles. In the HLA-DQB1 region, HLA-DQB1*06:02 allele was increased in these ABPA-CF patients with respect to AST and CF patients, and healthy controls, whereas HLA-DQB1*02:01 was decreased in ABPA-CF patients. These data confirm that a correlation exists between HLA-DRB1*15:01, -DRB1*11:04, DRB1*11:01, -DRB1*04 and -DRB1*07:01 alleles, and ABPA-CF susceptibility and suggest that HLA-DQB1*02:01 is an ABPA-CF resistance allele.
Authors:
Manuel Muro; Pedro Mondejar-López; María Rosa Moya-Quiles; Gema Salgado; María Dolores Pastor-Vivero; Ruth Lopez-Hernandez; Francisco Boix; José Antonio Campillo; Alfredo Minguela; Ana Garcia-Alonso; Manuel Sánchez-Solís; María Rocío Alvarez-López
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-28
Journal Detail:
Title:  Microbiology and immunology     Volume:  -     ISSN:  1348-0421     ISO Abbreviation:  Microbiol. Immunol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Immunology Service, University Hospital Virgen Arrixaca, Murcia, Spain.
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