Document Detail


HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis.
MedLine Citation:
PMID:  19995845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Until recently, neuromyelitis optica (NMO) was considered to be a sub-type of multiple sclerosis (MS), which has a strong predilection for Caucasian populations, whereas NMO is more frequent in non-Caucasian individuals. The objective of this study was to compare the HLA-DRB profile in Brazilian Mulatto patients with NMO spectrum disorders (NMOSDs) with that observed for Mulatto MS patients and healthy Mulatto controls. Twenty seven NMOSD patients (20 women), all seropositive for NMO-IgG, 29 MS patients and 28 Mulatto healthy blood donors were evaluated for HLA-DRB allele groups. HLA-DRB1*03 allele group was overrepresented in NMO patients compared with healthy controls (p = 0.0401; OR = 3.23, 95%CI: 1.07-9.82). In contrast, the HLA-DRB1*15 allele group was overrepresented in Brazilian MS patients (OR = 15.89, 95%CI: 3.51-71.85; p < 0.0001). DRB3 was overrepresented in NMO (p = 0.0064), and DRB5 overrepresented in MS patients (p = 0.0001). The low frequency of HLA-DRB1*15 alleles was associated with the presence of long and central cord lesions at magnetic resonance. In addition, DRB1*15 alleles were associated with the fulfillment of the Barkhof criteria. In conclusion, these results indicate that the DRB profile of NMO patients is different from that observed for MS patients, further corroborating the distinction between NMO and MS.
Authors:
Doralina Guimara?es Brum; Amilton Antunes Barreira; Antonio Carlos dos Santos; Damacio Ramon Kaimen-Maciel; Marcelo Matiello; Roberta Martins Costa; Neifi Hassan Saloun Deghaide; Laudo Silva Costa; Paulo Louzada-Junior; Paula Rejane Beserra Diniz; Elizabeth Regina Comini-Frota; Celso Teixeira Mendes-Junior; Eduardo Antonio Donadi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-07
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  16     ISSN:  1477-0970     ISO Abbreviation:  Mult. Scler.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-06     Completed Date:  2010-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Affiliation:
Division Neurology, Department of Neurosciences, Medical School of Ribeir?o Preto, University of S?o Paulo, Ribeir?o Preto, SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Alleles
Blood Donors
Brazil / epidemiology
Female
Gene Frequency
HLA-DR Antigens / genetics*
Histocompatibility Testing
Humans
Immunoglobulin G / immunology
Linkage (Genetics) / genetics
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis / epidemiology,  genetics*
Neuromyelitis Optica / epidemiology,  genetics*
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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