| HLA-DR8 and acute anterior uveitis in ankylosing spondylitis. | |
| | |
MedLine Citation:
|
PMID: 7718009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To identify possible factors in the development of acute anterior uveitis (AUU) in patients with ankylosing spondylitis (AS). METHODS: We investigated HLA antigens serologically, and HLA-DRB1*08 alleles by polymerase chain reaction-restriction fragment length polymorphism, in 42 Japanese AS patients with and without AAU. RESULTS: Thirty-six of the AS patients (85.7%) had HLA-B27. Thirteen (65%) of the 20 patients with AAU had HLA-DR8, whereas only 1 (4.5%) of the 22 patients without AAU had DR8. The difference was statistically significant (Pcorr < 0.001). CONCLUSION: Our data suggest that HLA-B27 is strongly associated with AS in Japanese patients and that HLA-DR8 is important for the development of AAU in Japanese patients with AS. |
| | |
Authors:
|
S M Monowarul Islam; J Numaga; Y Fujino; K Masuda; H Ohda; R Hirata; H Maeda; H Mitsui |
Related Documents
:
|
193479 - Increased cellular responsiveness to epinephrine in primary open-angle glaucoma. 4045849 - Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of... 20079929 - Correlation between ocular demodex infestation and serum immunoreactivity to bacillus p... 9284599 - Adverse drugs reactions associated with glaucoma medications. 20696979 - Canadian glaucoma study: 3. impact of risk factors and intraocular pressure reduction o... 3397859 - Ophthalmologic features of prader-willi syndrome. 2508139 - Seizure in gradual clonazepam withdrawal. 11243639 - Increased basic fibroblast growth factor levels in serum and blister fluid from patient... 17962989 - Correlation between retinal morphological and functional findings and clinical severity... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Arthritis and rheumatism Volume: 38 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-05-16 Completed Date: 1995-05-16 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 547-50 Citation Subset: AIM; IM |
Affiliation:
|
University of Tokyo School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adult Asian Continental Ancestry Group Base Sequence Female HLA Antigens / analysis, classification HLA-B27 Antigen / analysis HLA-DR Antigens / analysis* Humans Male Molecular Probes / genetics Molecular Sequence Data Reference Values Spondylitis, Ankylosing / complications, immunology* Uveitis, Anterior / complications, immunology* |
| Chemical | |
Reg. No./Substance:
|
0/HLA Antigens; 0/HLA-B27 Antigen; 0/HLA-DR Antigens; 0/HLA-DR8; 0/Molecular Probes |
| Comments/Corrections | |
Comment In:
|
Arthritis Rheum. 1996 Feb;39(2):351-2
[PMID:
8849392
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Knee osteoarthritis in former runners, soccer players, weight lifters, and shooters.
Next Document: The prevalence and incidence of systemic lupus erythematosus in Birmingham, England. Relationship to...