Document Detail

HLA-DR2 phenotype and plasma lysozyme, beta-glucuronidase and acid phosphatase levels in pulmonary tuberculosis.
MedLine Citation:
PMID:  9432375     Owner:  NLM     Status:  MEDLINE    
SETTING: Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India. OBJECTIVE: To elucidate the role of HLA-Class II genes/gene products on phagocyte enzymes such as lysozyme, beta-glucuronidase and acid phosphatase in the plasma of pulmonary tuberculosis patients. DESIGN: Serological determination of HLA-DR and -DQ antigens was carried out in 54 active and 84 inactive pulmonary tuberculosis (quiescent) patients and 36 healthy control subjects. The levels of lysozyme, beta-glucuronidase and acid phosphatase were measured in the plasma of tuberculosis patients and control subjects. RESULTS: Increased lysozyme levels were observed in active pulmonary tuberculosis patients. beta-glucuronidase activity was higher in inactive-TB than in active-TB patients and control subjects. HLA-DR2 positive patients showed a lower lysozyme level than -DR2 negative patients. CONCLUSION: Increase in the plasma lysozyme level in active TB reveals the active stage of the disease. Further, increase in the activity of beta-glucuronidase in inactive-TB patients reveals the quiescent stage of the disease. The low level of lysozyme in HLA-DR2 positive patients may also be one of the possible factors involved in susceptibility to tuberculosis.
P Selvaraj; M Kannapiran; A M Reetha; H Uma; T Xavier; P R Narayanan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  1     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1998-01-12     Completed Date:  1998-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  265-9     Citation Subset:  IM    
Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India.
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MeSH Terms
Acid Phosphatase / blood*
Glucuronidase / blood*
HLA-DR2 Antigen / genetics*
Histocompatibility Testing
Middle Aged
Muramidase / blood*
Tuberculosis, Pulmonary / diagnosis*,  enzymology,  genetics
Reg. No./Substance:
0/HLA-DR2 Antigen; EC Phosphatase; EC; EC

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