| HLA-DR2 phenotype and plasma lysozyme, beta-glucuronidase and acid phosphatase levels in pulmonary tuberculosis. | |
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MedLine Citation:
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PMID: 9432375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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SETTING: Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India. OBJECTIVE: To elucidate the role of HLA-Class II genes/gene products on phagocyte enzymes such as lysozyme, beta-glucuronidase and acid phosphatase in the plasma of pulmonary tuberculosis patients. DESIGN: Serological determination of HLA-DR and -DQ antigens was carried out in 54 active and 84 inactive pulmonary tuberculosis (quiescent) patients and 36 healthy control subjects. The levels of lysozyme, beta-glucuronidase and acid phosphatase were measured in the plasma of tuberculosis patients and control subjects. RESULTS: Increased lysozyme levels were observed in active pulmonary tuberculosis patients. beta-glucuronidase activity was higher in inactive-TB than in active-TB patients and control subjects. HLA-DR2 positive patients showed a lower lysozyme level than -DR2 negative patients. CONCLUSION: Increase in the plasma lysozyme level in active TB reveals the active stage of the disease. Further, increase in the activity of beta-glucuronidase in inactive-TB patients reveals the quiescent stage of the disease. The low level of lysozyme in HLA-DR2 positive patients may also be one of the possible factors involved in susceptibility to tuberculosis. |
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Authors:
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P Selvaraj; M Kannapiran; A M Reetha; H Uma; T Xavier; P R Narayanan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 1 ISSN: 1027-3719 ISO Abbreviation: Int. J. Tuberc. Lung Dis. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1998-01-12 Completed Date: 1998-01-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9706389 Medline TA: Int J Tuberc Lung Dis Country: FRANCE |
Other Details:
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Languages: eng Pagination: 265-9 Citation Subset: IM |
Affiliation:
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Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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blood* Adult Female Glucuronidase / blood* HLA-DR2 Antigen / genetics* Histocompatibility Testing Humans Male Middle Aged Muramidase / blood* Phenotype* Prognosis Tuberculosis, Pulmonary / diagnosis*, enzymology, genetics |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR2 Antigen; EC 3.1.3.2/Acid Phosphatase; EC 3.2.1.17/Muramidase; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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