Document Detail

HLA-DR typing of women with recurrent late spontaneous abortion and unsuccessful cervical cerclage.
MedLine Citation:
PMID:  9619574     Owner:  NLM     Status:  MEDLINE    
The release of certain cytokines, e.g. tumour necrosis factor (TNF)-alpha, in the amniotic fluid has been suggested to be a cause of preterm birth. The predisposition to excessive liberation of cytokines from peripheral leukocytes has been shown to depend partly on the individual's HLA-DR genotype. The HLA-DR1 and -DR3 alleles have previously been reported as being associated with a TNF-alpha high responder status and have also been associated with unexplained recurrent spontaneous abortions. In the present study, HLA-DR typing was performed in 10 women who had experienced recurrent very early preterm births resulting in perinatal death, or late spontaneous abortions under a clinical picture resembling that traditionally attributed to cervical incompetence. All patients had had at least one mid-trimester miscarriage in spite of the insertion of a cervical cerclage. Nine out of 10 (90%) patients had the HLA-DR phenotypes DR1 and/or DR3 compared with 37% in the background population (P < 0.005). The results suggest that HLA-DR-associated immunological factors might play a part in recurrent late spontaneous abortions and extremely preterm births under a cervical incompetence-like picture, at least in the subset of cases not treatable by cervical cerclage.
H Mohapeloa; O B Christiansen; N Grunnet
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-08-06     Completed Date:  1998-08-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1079-82     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Aalborg Hospital, Denmark.
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MeSH Terms
Abortion, Habitual / genetics,  immunology*,  surgery
Cervix Uteri / surgery*
HLA Antigens / classification*,  genetics
HLA-DR1 Antigen / analysis
HLA-DR3 Antigen / analysis
Suture Techniques*
Uterine Cervical Incompetence / immunology,  surgery*
Reg. No./Substance:
0/HLA Antigens; 0/HLA-DR1 Antigen; 0/HLA-DR3 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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