Document Detail

HLA-DR typing in polyarticular juvenile idiopathic arthritis: a study from a tertiary care hospital in northern India.
MedLine Citation:
PMID:  24618287     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Many studies of human leukocyte antigen (HLA) association with juvenile idiopathic arthritis (JIA) have reported conflicting results, which were probably related to ethnic differences. Moreover, in India, studies on HLA-DR typing on JIA, particularly polyarticular JIA, is lacking.
OBJECTIVE: The aim of our study was to reveal the frequency of HLA DR types in a cohort of polyarticular JIA in northern India.
METHODS: Fifty-two polyarticular JIA patients were included as per the recent International League of Associations for Rheumatology classification, 2001. HLA-DR typing was performed in 21 patients (18 rheumatoid factor [RF]+ and three RF-) by a DNA-based polymerase chain reaction method for the determination of HLA alleles using sequence specific primers (SSP). The results were compared with that of 23 healthy controls of the same age and sex.
RESULTS: HLA-DR4 was present in five cases (23%) in the diseased group while only in one case (4.3%) in the control group with a relative risk of 5.47, but when compared with only RF+ polyarticular JIA, HLA-DR4 was found to be significantly high (27.7% vs. 4.43%; P < 0.05) with a relative risk of 6.3. Further, DR4, DR1, DR2, DR9, DR10 were also non-significantly high in these patients with relative risk of 3.2 for DR9 and 1.8 for DR10. In contrast, HLA-DR6 was seen only in 5.5% of polyarticular JIA cases, whereas it was present in 39% of controls (P < 0.05), a showing negative association.
CONCLUSION: HLA-DR4 codes for susceptibility to RF+ polyarticular JIA with a six-fold risk, whereas HLA-DR6 offers protection.
Behera Dibya Ranjan; Singh Nand Kumar; Singh Usha; Verma Pramod Kumar
Related Documents :
3966757 - Thyroid abnormalities in dermatitis herpetiformis. prevalence of clinical thyroid disea...
6329967 - Antibody-dependent cellular cytotoxicity and disease course in north american patients ...
17595457 - Comparative analysis of blood redox parameters according thyroid function of patients w...
21237657 - Lumboperitoneal shunt in a patient with behçet's disease with medically refractory intr...
23421407 - Incidence rate and clinical features of hyperthyroidism in a long-term iodine sufficien...
21590527 - Cognitive functioning in female patients with 21-hydroxylase deficiency.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-1
Journal Detail:
Title:  International journal of rheumatic diseases     Volume:  -     ISSN:  1756-185X     ISO Abbreviation:  Int J Rheum Dis     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2014-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474930     Medline TA:  Int J Rheum Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recent accomplishments in wound healing.
Next Document:  Urinary immunocytology-Promise or nonseller? A review with an opinion.