Document Detail

HLA-DR factors associated with postpartum hypothyroidism: an early manifestation of Hashimoto's thyroiditis?
MedLine Citation:
PMID:  3672491     Owner:  NLM     Status:  MEDLINE    
Thirty-three Danish women selected from a prospective study of postpartum thyroiditis were HLA-DR typed. All women had positive titers of antimicrosomal antibodies, and 20 women developed thyroid dysfunction after delivery. DR5 and the phenotype 4.5 were significantly increased in the whole group (p less than 0.001) and strongly associated to hypothyroidism (p less than 0.01), whereas DR3 was insignificantly increased in thyrotoxic women. It is concluded that postpartum hypothyroidism is an autoimmune disorder and may be an early manifestation of Hashimoto's thyroiditis.
O Pryds; H H Lervang; H P Kristensen; B K Jakobsen; A Svejgaard
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  30     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-12-17     Completed Date:  1987-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  34-7     Citation Subset:  IM    
Department of Paediatrics, Central Hospital of Naestved, Denmark.
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MeSH Terms
HLA Antigens / analysis
HLA-D Antigens / analysis*
HLA-DR Antigens / analysis*
Hypothyroidism / immunology*
Microsomes / immunology
Postpartum Period*
Thyroid Gland / immunology*
Thyroiditis, Autoimmune / immunology*
Thyrotoxicosis / immunology*
Reg. No./Substance:
0/HLA Antigens; 0/HLA-D Antigens; 0/HLA-DR Antigens

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