Document Detail


HLA-DR expression in peripheral neuropathies: the role of Schwann cells, resident and hematogenous macrophages, and endoneurial fibroblasts.
MedLine Citation:
PMID:  7709733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of HLA-DR and the macrophage marker CD 68 was studied in 44 sural nerve biopsies from patients with inflammatory and non-inflammatory neuropathies and controls using immunohistochemistry on non-osmicated semithin sections, a technique that has not been used before in such a biopsy study. Most HLA-DR-immunoreactive (ir) cells were fibroblasts, macrophages or perineural cells, some were perivascular and endothelial cells, and only few were Schwann cells. Counts of immunoreactive cells revealed (a) increased HLA-DR expression in severe as compared to less severe neuropathies and to controls, (b) no correlation between the numbers of HLA-DR-ir cells and CD 68-ir macrophages, and (c) no close correlation between diagnostic groups and the number of HLA-DR-ir cells, but higher numbers in inflammatory neuropathies. We conclude that endoneurial fibroblasts and macrophages as antigen-presenting cells may be mediators in various peripheral nerve diseases, not only in inflammatory disorders.
Authors:
C Sommer; J M Schröder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  89     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-05-10     Completed Date:  1995-05-10     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  63-71     Citation Subset:  IM    
Affiliation:
Institut für Neuropathologie, Klinikum der Rheinisch-Westfälischen Technischen Hochschule, Aachen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biopsy
Child
Fibroblasts / immunology*
HLA-DR Antigens / analysis*
Humans
Immunohistochemistry
Macrophages / immunology*
Male
Middle Aged
Peripheral Nerves / chemistry,  immunology
Peripheral Nervous System Diseases / immunology*,  pathology
Schwann Cells / immunology*
Sural Nerve / chemistry,  immunology
Chemical
Reg. No./Substance:
0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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