Document Detail


HLA-DR antigens: cellular expression and molecular structure
MedLine Citation:
PMID:  6187269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The HLA complex encodes several sets of membrane glycoproteins with extensive genetic, functional and structural polymorphism. The HLA-D region and its products, the HLA-DR antigens, are central in immune phenomena. They control the mixed lymphocyte reaction, the graft versus host reaction in vivo and cell/cell interactions involved in immune responses. Monoclonal anti HLA-DR antigens have been used to investigate the expression and synthesis of human Ia antigens on B and active T lymphocytes and macrophages. They were subsequently used in structural studies of HLA-DR antigens analysed by two-dimensional gel electrophoresis. The HLA-DR antigens are composed of a bimolecular complex of two non-covalently linked subunits: a 34,000 dalton alpha chain and a 29,000 dalton beta chain. Glycosylation steps and molecular maturation include the addition of oligosaccharides and sialic acid residues to the native polypeptide chain. The structural polymorphism which correlates with the serologically defined HLA-DR determinants is localized on the beta chain and is of polypeptidic origin. A third component of the HLA-DR antigen is described: the 31,000-dalton "invariant" chain. Its peptide composition, glycosylation pattern and expression are reported. Homologies of HLA-DR antigens with the mouse Ia antigens are discussed. Structural studies of the human Ia system are important in dissecting the functional role of the different epitopes of the HLA-DR molecules.
Authors:
D J Charron
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Annales d'immunologie     Volume:  133D     ISSN:  0300-4910     ISO Abbreviation:  Ann. Immunol. (Paris)     Publication Date:    1982 Sep-Oct
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0353045     Medline TA:  Ann Immunol (Paris)     Country:  FRANCE    
Other Details:
Languages:  fre     Pagination:  155-69     Citation Subset:  IM    
Vernacular Title:
Les antigènes HLA-DR: expression cellulaire et structure moléculaire.
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology
Chemical Phenomena
Chemistry
Epitopes / genetics
Genes, MHC Class II
HLA-DR Antigens
Histocompatibility Antigens Class II* / analysis*,  isolation & purification
Humans
Lymphocyte Activation
Macrophages / immunology
Mice
Molecular Weight
Polymorphism, Genetic
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/Epitopes; 0/HLA-DR Antigens; 0/Histocompatibility Antigens Class II

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