Document Detail


HLA-DPbeta chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  18186799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertrophic cardiomyopathy (HCM) is a heart muscle disease characterized by hypertrophy and diastolic dysfunction of cardiac ventricles. It is suggested that one possible aetiology of HCM is the hepatitis C virus (HCV) infection, but molecular mechanisms underlying development of HCV-associated HCM (HCV-HCM) remains unknown. Because the human leucocyte antigen (HLA) molecule is involved in the control of progression/suppression of viral infection, extensive HLA allelic diversity may modulate the post-infectious course of HCV and pathogenesis of HCV-HCM. Here we undertook a case-control study with 38 patients with HCV-HCM and 132 unrelated healthy controls to reveal the potential impact of polymorphisms in seven classical and two non-classical HLA genes on the pathogenesis of HCV-HCM. It was found that DPB1*0401 and DPB1*0901 were significantly associated with increased risk to HCV-HCM in dominant model (P < 0.028, OR = 3.94, 95% confidence interval (CI) = 1.19, 13.02) and in recessive model (P < 0.007, OR = 9.85, 95% CI = 1.83, 53.04), respectively. The disparity in the gene-dose effect by two susceptible DPB1 alleles may be attributable to the difference between the susceptible (36 A and 55 A) and resistant (8L, 9F, 11G, 57E and 76M) residue-combination consisting of DPbeta anchor pocket for antigenic peptide-binding. These results implied that the HLA-DP molecules with specificity pocket appropriate for HCV antigen(s) might confer the progressive process of HCM among the HCV-infected individuals.
Authors:
D Shichi; A Matsumori; T K Naruse; H Inoko; A Kimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of immunogenetics     Volume:  35     ISSN:  1744-313X     ISO Abbreviation:  Int. J. Immunogenet.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-11     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101232337     Medline TA:  Int J Immunogenet     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Affiliation:
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Viral / immunology
Asian Continental Ancestry Group / genetics
Cardiomyopathy, Hypertrophic / genetics*,  immunology
Case-Control Studies
Genetic Predisposition to Disease*
HLA-DP Antigens / chemistry,  genetics*
Hepacivirus / immunology
Hepatitis C / genetics*,  immunology
Humans
Polymorphism, Genetic
Chemical
Reg. No./Substance:
0/Antigens, Viral; 0/HLA-DP Antigens

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