Document Detail


HLA-DP in rheumatoid arthritis.
MedLine Citation:
PMID:  3259737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Frequencies of HLA-DR, Dw and DPw specificities were compared between rheumatoid arthritis (RA) patients, Felty's syndrome (FS) patients and normal controls. It was confirmed that the frequency of DR4 was increased in RA patients (54% (n = 111) vs 23% (n = 272), relative risk (RR) = 3.98, P less than 0.001). Cellular typing showed a highly significant increase in HLA-Dw14 in the entire RA population (17% (n = 32) vs 2% (n = 242), RR = 11.90, P less than 0.001), and a tendency towards an increase of HLA-Dw14 in DR4+ RA patients compared to DR4+ controls (28% (n = 32) vs 11% (n = 47), RR = 3.29, P less than 0.05). Regarding DPw specificities, the only significance was for a negative association with DPw3 (13% vs 22% (n = 254), RR = 0.51, P less than 0.05), with an additional tendential decrease of DPw1 (11% vs 19%, RR = 0.53, not significant (NS]. The decrease of DPw3 was more marked in DR4- RA patients (RR = 0.33, P less than 0.05) than in DR4+ RA patients (RR = 0.69, NS). In FS patients, 96% of whom were DR4+, decreased DPw1 was very marked, whereas the frequency of DPw3 was unaltered compared to DR4+ normals. These alterations in frequencies were not caused by linkage disequilibria between HLA-DR and -DP alleles. Thus, taken together, these data suggest that, in the presence of the major DR4-associated "susceptibility" gene(s) for RA, DPw1 may have "protective" effects, whereas in the absence of DR4, the presence of DPw3 has significant "protective" activity.
Authors:
G Pawelec; P Reekers; D Brackertz; D Sansom; E M Schneider; M Blaurock; C Müller; A Rehbein; I Balko; P Wernet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  31     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-07-08     Completed Date:  1988-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Affiliation:
Immunology Laboratory, Medizinische Klinik, Tübingen, FRG.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / genetics*
Felty's Syndrome / genetics
Gene Frequency
HLA-D Antigens / genetics*
HLA-DP Antigens / genetics*
HLA-DR Antigens / genetics
HLA-DR1 Antigen
HLA-DR4 Antigen
Humans
Linkage (Genetics)
Chemical
Reg. No./Substance:
0/HLA-D Antigens; 0/HLA-DP Antigens; 0/HLA-DP3; 0/HLA-DR Antigens; 0/HLA-DR1 Antigen; 0/HLA-DR4 Antigen; 0/HLA-Dw14

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