Document Detail

HLA Class II high resolution genotyping in Greek children with celiac disease and impact in disease susceptibility.
MedLine Citation:
PMID:  23041663     Owner:  NLM     Status:  Publisher    
Background:Celiac disease (CD) has been associated with HLA class II heterodimers. This study aimed at determining the HLA genotypic and allelic distribution in Greek children with CD compared to the general population.Methods:118 children with CD and 120 healthy individuals serving as controls were included in the study.Results:Higher frequencies for HLA - DQB1*02:01 were observed in CD patients (40.25% vs 9.58%, p<0.001) and DQB1*02:02 (20.34% vs 5.42%, p<0.001), while HLA-DQB1*03:01 (16.53% vs 30.42%, p<0.001), DQB1*05:01 (0.85% vs 10%, p<0.001) and DQB1*05:02 (5.51% vs 17.92%, p<0.001) were significantly lower, compared to the controls. DQA1*02:01 (CD-patients vs controls: 20.76% vs 6.67%, p<0.001) and DQA1*05:01 (40.25% vs 9.58%, p<0.001) were significantly more frequent in patients. The frequencies of HLA-DQA1* 01:01, *01:02, *01:04 and *05:05 were significantly lower in patients (p<0.001). The haplotype mainly associated with CD was DRB1*03-DQB1*02:01-DQA1*05:01; CD-patients vs controls: 39.83% vs 9.58%, p<0.001. In total, 84.75% of patients carried DQ2 (vs 21.67% in controls, p<0.001), while 11.02% were DQ8 positive/DQ2 negative.Conclusion:This study confirms the existing and provides additional evidence supporting a strong genetic predisposition for CD associated with the class II alleles DQB1*02- DQA1*05 encoding the serological specificity DQ2.Pediatric Research (2012); doi:10.1038/pr.2012.133.
Maro Krini; Giorgos Chouliaras; Maria Kanariou; Ioanna Varela; Kleopatra Spanou; Joanna Panayiotou; Eleftheria Roma; Nikki Constantinidou
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-05
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
First Department of Pediatrics, University of Athens Medical School, Athens, Attica, Greece.
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