| HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile. | |
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MedLine Citation:
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PMID: 23293357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The MHC in humans encodes the most polymorphic genes, the HLA genes, which are critical for the immune system to clear infection. This can be attributed to strong selection pressure as populations moved to different parts of the world and encountered new kinds of infections, leading to new HLA class II alleles. HLA genes also have the highest relative risk for autoimmune diseases. Three haplotypes, that is, HLA-DR2DQ6, DR4DQ8, and DR3DQ2, account for HLA association with most autoimmune diseases. We hypothesize that these haplotypes, along with their multiple subtypes, have survived bottlenecks of infectious episodes in human history because of their ability to present pathogenic peptides to activate T cells that secrete cytokines to clear infections. Unfortunately, they also present self-peptides/mimics to activate autoreactive T cells secreting proinflammatory cytokines that cause autoimmune diseases. |
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Authors:
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Ashutosh K Mangalam; Veena Taneja; Chella S David |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 190 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-07 Completed Date: 2013-03-14 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 513-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. mangalam.ashutosh@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / genetics*, immunology*, prevention & control Autoimmunity / genetics, immunology CD4-Positive T-Lymphocytes / immunology Cytokines / metabolism* Disease Susceptibility* / immunology HLA-D Antigens / genetics*, immunology* Haplotypes Humans T-Lymphocyte Subsets |
| Grant Support | |
ID/Acronym/Agency:
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AI75262/AI/NIAID NIH HHS; AR30752/AR/NIAMS NIH HHS; AR60077/AR/NIAMS NIH HHS; NS52173/NS/NINDS NIH HHS; R01 AI075262/AI/NIAID NIH HHS; R01 AR030752/AR/NIAMS NIH HHS; R01 NS052173/NS/NINDS NIH HHS; R21 AR060077/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/HLA-D Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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