Document Detail


HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile.
MedLine Citation:
PMID:  23293357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The MHC in humans encodes the most polymorphic genes, the HLA genes, which are critical for the immune system to clear infection. This can be attributed to strong selection pressure as populations moved to different parts of the world and encountered new kinds of infections, leading to new HLA class II alleles. HLA genes also have the highest relative risk for autoimmune diseases. Three haplotypes, that is, HLA-DR2DQ6, DR4DQ8, and DR3DQ2, account for HLA association with most autoimmune diseases. We hypothesize that these haplotypes, along with their multiple subtypes, have survived bottlenecks of infectious episodes in human history because of their ability to present pathogenic peptides to activate T cells that secrete cytokines to clear infections. Unfortunately, they also present self-peptides/mimics to activate autoreactive T cells secreting proinflammatory cytokines that cause autoimmune diseases.
Authors:
Ashutosh K Mangalam; Veena Taneja; Chella S David
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  190     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-03-14     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / genetics*,  immunology*,  prevention & control
Autoimmunity / genetics,  immunology
CD4-Positive T-Lymphocytes / immunology
Cytokines / metabolism*
Disease Susceptibility* / immunology
HLA-D Antigens / genetics*,  immunology*
Haplotypes
Humans
T-Lymphocyte Subsets
Grant Support
ID/Acronym/Agency:
AI75262/AI/NIAID NIH HHS; AR30752/AR/NIAMS NIH HHS; AR60077/AR/NIAMS NIH HHS; NS52173/NS/NINDS NIH HHS; R01 AI075262/AI/NIAID NIH HHS; R01 AR030752/AR/NIAMS NIH HHS; R01 NS052173/NS/NINDS NIH HHS; R21 AR060077/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/HLA-D Antigens
Comments/Corrections

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