| HLA class II alleles susceptibility markers of type 1 diabetes fail to specify phenotypes of ketosis-prone diabetes in adult Tunisian patients. | |
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MedLine Citation:
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PMID: 21461382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We aimed to characterize the different subgroups of ketosis-prone diabetes (KPD) in a sample of Tunisian patients using the Aβ scheme based on the presence or absence of β-cell autoantibodies (A+ or A-) and β-cell functional reserve (β+ or β-) and we investigated whether HLA class II alleles could contribute to distinct KPD phenotypes. We enrolled 43 adult patients with a first episode of ketosis. For all patients we evaluated clinical parameters, β-cell autoimmunity, β-cell function and HLA class II alleles. Frequency distribution of the 4 subgroups was 23.3% A+β-, 23.3% A-β-, 11.6% A+β+ and 41.9% A-β+. Patients from the group A+β- were significantly younger than those from the group A-β- (P = .002). HLA susceptibility markers were significantly more frequent in patients with autoantibodies (P = .003). These patients also had resistance alleles but they were more frequent in A+β+ than A+β- patients (P = .04). Insulin requirement was not associated to the presence or the absence of HLA susceptibility markers. HLA class II alleles associated with susceptibility to autoimmune diabetes have not allowed us to further define Tunisian KPD groups. However, high prevalence of HLA resistance alleles in our patients may reflect a particular genetic background of Tunisian KPD population. |
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Authors:
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Lilia Laadhar; Fatma Harzallah; Mondher Zitouni; Maryam Kallel-Sellami; Moncef Fekih; Naziha Kaabachi; Hádia Slimane; Sondès Makni |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-02 |
Journal Detail:
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Title: Experimental diabetes research Volume: 2011 ISSN: 1687-5303 ISO Abbreviation: Exp Diabetes Res Publication Date: 2011 |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-07-18 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101274844 Medline TA: Exp Diabetes Res Country: United States |
Other Details:
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Languages: eng Pagination: 964160 Citation Subset: IM |
Affiliation:
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Immunology Department, La Rabta Hospital, Al Manar University Tunis, Tunisia. lilia_laadhar@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / blood Diabetes Mellitus, Type 1 / drug therapy, epidemiology, genetics*, immunology, metabolism Diabetic Ketoacidosis / epidemiology, genetics*, immunology, metabolism Female Gene Frequency Genetic Markers Genotype HLA-DQ Antigens / genetics*, immunology HLA-DR Antigens / genetics*, immunology Humans Hypoglycemic Agents / therapeutic use Insulin / therapeutic use Insulin-Secreting Cells / drug effects, immunology, metabolism Male Middle Aged Phenotype Prospective Studies Tunisia / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Genetic Markers; 0/HLA-DQ Antigens; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 128338-86-3/HLA-DRB1 antigen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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