Document Detail


HLA-Bw52 in Takayasu disease.
MedLine Citation:
PMID:  31708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Takayasu disease is characterized by a pulseless condition which most often occurs in young females from Asian or South American areas. The cause of this disease remains obscure. Recently we encountered monozygotic, Japanese identical twin sisters, both of whom were diagnosed as having Takayasu disease. A genetically related factor was considered and HLA analysis was carried out. A population study on HLA typing analyses of 65 patients with Takayasu disease revealed a high frequency of HLA-B5 as compared with 128 healthy Japanese (chi2 :17.0, P less than 10(-4)). Subgroups of B5, Bw51 and Bw52 were successively studied in 82 patients with this disease. Bw51 antigen was found in 12.2% of patients with Takayasu disease and in 19.5% of 128 healthy Japanese. Contrarily, Bw52 antigen was confirmed in 43.9% of patients, a statistically significant frequency with the level of 26.5 in the chi2 test (cP less than 3 x 10(-4)) when compared with 12.5% in normal Japanese. Thus a genetically related factor in the pathogenesis of Takayasu disease has to be considered.
Authors:
I Isohisa; F Numano; H Maezawa; T Sasazuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  12     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-02-12     Completed Date:  1979-02-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  246-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aortic Arch Syndromes / genetics*
Diseases in Twins*
HLA Antigens* / analysis
Humans
Takayasu Arteritis / genetics*
Chemical
Reg. No./Substance:
0/HLA Antigens

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