| HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients. | |
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MedLine Citation:
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PMID: 15113995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Carriage of HLA-B60 has been shown to increase the risk of ankylosing spondylitis (AS) in B27-positive Caucasian patients, but the association in B27-negative cases is less certain. This study assessed HLA class I gene associations in Chinese HLA-B27-negative AS patients. METHODS: Forty-one Chinese HLA-B27-negative AS patients fulfilling the modified New York diagnostic criteria for AS were recruited, and 11 383 HLA-B27-negative blood donors were used for comparison. HLA-A and -B typing was done with the microlymphocytotoxicity assay. RESULTS: Among the B27-negative AS patients, 21 were male and 20 were female. Of HLA-B alleles, only B60 and B61 significantly increased susceptibility to AS in HLA-B27-negative patients (P<0.001). CONCLUSIONS: In Taiwan Chinese, carriage of B60 is increased in HLA-B27-negative AS patients. The association between B61 and HLA-B27-negative AS patients has not been reported previously. Whether the gene involved is HLA-B60 or B61 or another gene in linkage disequilibrium with these genes is unknown. |
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Authors:
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J C C Wei; W C Tsai; H S Lin; C Y Tsai; C T Chou |
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Publication Detail:
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Type: Journal Article Date: 2004-04-27 |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 43 ISSN: 1462-0324 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-23 Completed Date: 2004-08-30 Revised Date: 2007-09-06 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: 839-42 Citation Subset: AIM; IM |
Affiliation:
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Division of Allergy-Immunology-Rheumatology, Veterans General Hospital-Taipei, No. 201, Sec. 2, Shpai Road, Beitou Chiu, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies China / ethnology Female Flow Cytometry Genes, MHC Class I HLA-B Antigens / analysis* HLA-B27 Antigen / analysis Humans Immunophenotyping Joints / ultrasonography Male Middle Aged Spondylitis, Ankylosing / genetics, immunology*, ultrasonography Taiwan Ultrasonography, Doppler |
| Chemical | |
Reg. No./Substance:
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0/HLA-B Antigens; 0/HLA-B27 Antigen; 0/HLA-B60; 0/HLA-B61 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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