| HLA-B*51 allele analysis by the PCR-SBT method and a strong association of HLA-B*5101 with Japanese patients with Behçet's disease. | |
| | |
MedLine Citation:
|
PMID: 11703826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Behçet's disease (BD) is known to be associated with human leukocyte antigen (HLA) B51 in many different ethnic groups. An increased incidence of HLA-B51 in the patient group has also been reported in a Japanese population. Recently, the B51 antigen has been identified to comprise 21 alleles, B*5101-B*5121. Further, not only HLA-B*5101 but also HLA-B*5108 were found to be relatively increased in the patient groups among Italian and Saudi Arabian populations. Therefore, we performed HLA-B*51 allele genotyping by the polymerase chain reaction-sequencing based typing (PCR-SBT) method in order to investigate whether there is any correlation of one particular B51-associated allele with Japanese BD. Ninety-six Japanese patients with BD and 132 healthy Japanese volunteers were enrolled in this study. As a result, the phenotype frequency of the B51 antigen was confirmed to be remarkably increased in the patient group as compared to the ethnically matched control group (59.4% in patients vs. 13.6% in controls; Pc=0.0000000000098, R.R.=9.3). In the B*51 allele genotyping, 56 out of 57 B51-positive patients were defined as B*5101 and the remaining one was B*5102. In contrast, all of 18 B51-positive normal controls were B*5101. None of the Japanese patients and healthy controls carried the HLA-B*5108 allele. This study revealed that B*51 allelic distribution in Japanese was different from those in Italian and Saudi Arabian populations, and that the significantly high incidence of the HLA-B51 antigen in the Japanese BD patient group was mostly caused by the significant increase of the HLA-B*5101 allele. |
| | |
Authors:
|
N Mizuki; M Ota; Y Katsuyama; K Yabuki; H Ando; T Shiina; E Nomura; K Onari; S Ohno; H Inoko |
Related Documents
:
|
8039226 - High incidence of renal artery stenosis in patients with coronary artery disease. 8789876 - Adult seronegative arthritis with antinuclear antibodies: a distinct group of patients ... 6785436 - D-penicillamine-induced increase in intracellular glutathione correlating to clinical r... 19326186 - Efficacy of mizoribine pulse therapy in patients with rheumatoid arthritis who show a r... 19120046 - Pathological dissociation and neuropsychological functioning in borderline personality ... 10025426 - Clinical correlations in 16 patients with total or partial laminin alpha2 deficiency ch... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Tissue antigens Volume: 58 ISSN: 0001-2815 ISO Abbreviation: Tissue Antigens Publication Date: 2001 Sep |
Date Detail:
|
Created Date: 2001-11-12 Completed Date: 2002-01-25 Revised Date: 2010-11-29 |
Medline Journal Info:
|
Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
|
Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
|
Department of Ophthalmology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alleles* Behcet Syndrome / genetics* Gene Frequency Genes, MHC Class I Genetic Predisposition to Disease* Genotype HLA-B Antigens / genetics* Histocompatibility Testing Humans Japan Polymerase Chain Reaction / methods |
| Chemical | |
Reg. No./Substance:
|
0/HLA-B Antigens; 0/HLA-B51 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ligation of major histocompatibility complex class I antigens (MHC-I) prevents apoptosis induced by ...
Next Document: Allelic distribution of HLA-B*5 in HLA-B5-positive Israeli patients with Behçet's disease.