Document Detail

HLA-B27 testing in ankylosing spondylitis: an analysis of the pretesting assumptions.
MedLine Citation:
PMID:  2526875     Owner:  NLM     Status:  MEDLINE    
Typing for histocompatibility antigen HLA-B27 has been suggested as a useful diagnostic test for ankylosing spondylitis (AS) in certain clinical situations. The appropriate use of any diagnostic test requires the clinician to estimate the likelihood of disease before the test is performed. One clinical situation in which B27 testing has been suggested to be useful is in the investigation of a patient with low back pain suggestive of AS but with normal sacroiliac radiographs. We analyze here the sequence of steps taken by the clinican in estimating the likelihood of AS. The assumptions that must be made to render B27 typing useful are calculated.
M Baron; I Zendel
Related Documents :
24169055 - Hypersensitivity to antihistamines.
25235965 - Assessing functional auditory performance in hearing-impaired listeners with an updated...
20926495 - Sensitivity and specificity of the ankle--brachial index to diagnose peripheral artery ...
15519595 - Quantification of human motion: gait analysis-benefits and limitations to its applicati...
16583985 - Lipophilicity, antifungal and antioxidant properties of persilben.
3512605 - The tm-sidhi programme, age, and brief tests of perceptual-motor speed and nonverbal in...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  16     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  631-4; discussion 634-6     Citation Subset:  IM    
Department of Medicine, McGill University, Montreal, PQ, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Back Pain / etiology
Bayes Theorem
Decision Support Techniques*
Diagnosis, Differential
HLA-B Antigens / analysis*
HLA-B27 Antigen
Predictive Value of Tests
Spondylitis, Ankylosing / diagnosis*
Reg. No./Substance:
0/HLA-B Antigens; 0/HLA-B27 Antigen
Erratum In:
J Rheumatol 1989 Jul;16(7):1014

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Semen characteristics and testosterone profiles in ferrets kept in a long-day photoperiod, and the i...
Next Document:  Immune complex disease and gynecomastia.