Document Detail

HLA-B27 testing in ankylosing spondylitis: an analysis of the pretesting assumptions.
MedLine Citation:
PMID:  2526875     Owner:  NLM     Status:  MEDLINE    
Typing for histocompatibility antigen HLA-B27 has been suggested as a useful diagnostic test for ankylosing spondylitis (AS) in certain clinical situations. The appropriate use of any diagnostic test requires the clinician to estimate the likelihood of disease before the test is performed. One clinical situation in which B27 testing has been suggested to be useful is in the investigation of a patient with low back pain suggestive of AS but with normal sacroiliac radiographs. We analyze here the sequence of steps taken by the clinican in estimating the likelihood of AS. The assumptions that must be made to render B27 typing useful are calculated.
M Baron; I Zendel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  16     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-09-01     Completed Date:  1989-09-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  631-4; discussion 634-6     Citation Subset:  IM    
Department of Medicine, McGill University, Montreal, PQ, Canada.
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MeSH Terms
Back Pain / etiology
Bayes Theorem
Decision Support Techniques*
Diagnosis, Differential
HLA-B Antigens / analysis*
HLA-B27 Antigen
Predictive Value of Tests
Spondylitis, Ankylosing / diagnosis*
Reg. No./Substance:
0/HLA-B Antigens; 0/HLA-B27 Antigen
Erratum In:
J Rheumatol 1989 Jul;16(7):1014

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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