Document Detail

HLA-B27 polymorphism in patients with juvenile and adult-onset ankylosing spondylitis in Southern China.
MedLine Citation:
PMID:  20196819     Owner:  NLM     Status:  MEDLINE    
Distribution of B27 subtypes in juvenile and adult-onset ankylosing spondylitis (JAS and AAS) in Southern China was studied. A total of 505 patients belonged to Han population were included (145 JAS and 360 AAS patients), and 1368 healthy individuals were included as controls. Human leukocyte antigen (HLA)-B27 typing was performed by Luminex liquid array combining polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) and/or serological method. HLA-B27 subtyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The sequence-based typing was performed for the B*2715 samples to verify the PCR-SSP results. HLA-B27 was presented in 453 of 505 patients (89.7%), compared with 74 of 1368 controls (5.41%). B*2704 subtype in AS group was significantly higher than controls and B*2705 subtype significantly lower. B*2715 and B*2702 were found in 1.32% and 0.66% of the B27-positive patients but none in controls, and there was no significant difference between either of them and controls. B27-positive patients were 134 (92.4%) in JAS group and 319 (88.6%) in AAS group. There was no significant difference for B27 subtypes distribution between JAS (B*2704, 05, 15) and AAS (B*2704, 05, 15, 02) groups. The frequency of B*2715 in two groups was 3 (2.24%) and 3 (0.94%), respectively. The onset age of three JAS patients carrying B*2715 was 5, 9 and 13 years old, respectively. Our results suggested that B*2704 was the predominant subtype in AS patients in Southern China. B*2715 was observed in AS group only and slightly more in JAS than in AAS, and the patients carrying this allele tended to have early onset, B*2715 may be disease-association subtype.
Y Mou; Z Wu; J Gu; Z Liao; Z Lin; Q Wei; J Huang; Q Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  75     ISSN:  1399-0039     ISO Abbreviation:  Tissue Antigens     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  56-60     Citation Subset:  IM    
Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
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MeSH Terms
Age of Onset
Genetic Association Studies
Genetic Predisposition to Disease
HLA-B27 Antigen / genetics*
Polymorphism, Genetic
Spondylitis, Ankylosing / epidemiology,  genetics*
Young Adult
Reg. No./Substance:
0/HLA-B27 Antigen
Comment In:
Tissue Antigens. 2010 Jan;75(1):9-11   [PMID:  20196817 ]

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