| HLA-B27 polymorphism in patients with juvenile and adult-onset ankylosing spondylitis in Southern China. | |
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MedLine Citation:
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PMID: 20196819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Distribution of B27 subtypes in juvenile and adult-onset ankylosing spondylitis (JAS and AAS) in Southern China was studied. A total of 505 patients belonged to Han population were included (145 JAS and 360 AAS patients), and 1368 healthy individuals were included as controls. Human leukocyte antigen (HLA)-B27 typing was performed by Luminex liquid array combining polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) and/or serological method. HLA-B27 subtyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The sequence-based typing was performed for the B*2715 samples to verify the PCR-SSP results. HLA-B27 was presented in 453 of 505 patients (89.7%), compared with 74 of 1368 controls (5.41%). B*2704 subtype in AS group was significantly higher than controls and B*2705 subtype significantly lower. B*2715 and B*2702 were found in 1.32% and 0.66% of the B27-positive patients but none in controls, and there was no significant difference between either of them and controls. B27-positive patients were 134 (92.4%) in JAS group and 319 (88.6%) in AAS group. There was no significant difference for B27 subtypes distribution between JAS (B*2704, 05, 15) and AAS (B*2704, 05, 15, 02) groups. The frequency of B*2715 in two groups was 3 (2.24%) and 3 (0.94%), respectively. The onset age of three JAS patients carrying B*2715 was 5, 9 and 13 years old, respectively. Our results suggested that B*2704 was the predominant subtype in AS patients in Southern China. B*2715 was observed in AS group only and slightly more in JAS than in AAS, and the patients carrying this allele tended to have early onset, B*2715 may be disease-association subtype. |
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Authors:
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Y Mou; Z Wu; J Gu; Z Liao; Z Lin; Q Wei; J Huang; Q Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tissue antigens Volume: 75 ISSN: 1399-0039 ISO Abbreviation: Tissue Antigens Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
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Languages: eng Pagination: 56-60 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age of Onset Child China Genetic Association Studies Genetic Predisposition to Disease HLA-B27 Antigen / genetics* Humans Polymorphism, Genetic Spondylitis, Ankylosing / epidemiology, genetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/HLA-B27 Antigen |
| Comments/Corrections | |
Comment In:
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Tissue Antigens. 2010 Jan;75(1):9-11
[PMID:
20196817
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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