Document Detail

HLA-B27 and ankylosing spondylitis: tales from China.
MedLine Citation:
PMID:  20196817     Owner:  NLM     Status:  MEDLINE    
The two most frequent HLA-B27 subtypes worldwide are B*2704 and B*2705. In the Han population of China B*2704 and, to a lower extent, B*2705 are found with significant frequency, and both are associated to ankylosing spondylitis (AS). Two articles in this issue report that the association to AS in this ethnic group is stronger for B*2704 than for B*2705. Thus, at least among the Han, B*2704 would be the strongest known susceptibility factor for AS.
J A López de Castro
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tissue antigens     Volume:  75     ISSN:  1399-0039     ISO Abbreviation:  Tissue Antigens     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  9-11     Citation Subset:  IM    
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain.
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MeSH Terms
Asian Continental Ancestry Group
Genetic Predisposition to Disease*
HLA-B27 Antigen / genetics*
Spondylitis, Ankylosing / epidemiology,  ethnology,  genetics*
Reg. No./Substance:
0/HLA-B27 Antigen
Comment On:
Tissue Antigens. 2010 Jan;75(1):61-4   [PMID:  19804562 ]
Tissue Antigens. 2010 Jan;75(1):56-60   [PMID:  20196819 ]

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