| HLA-B27 Prevalence in Arab Populations and Among Patients with Ankylosing Spondylitis. | |
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MedLine Citation:
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PMID: 22753660 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate prevalence of HLA-B27 among general Arab populations and among patients with ankylosing spondylitis (AS), and to review published data. METHODS: The prevalence of HLA-B27 was studied among 2579 unrelated healthy Jordanians, almost equally divided among Palestinian refugees and natives of Jordan, reflecting the general population of Jordan. The prevalence of HLA-B27 was also studied among 129 patients with AS, 70 from Jordan, and the remaining 59 from Qatar. HLA typing was performed by standard 2-stage micro-lymphocytotoxicity method. We also reviewed published English language studies of HLA-B27 in Arab patients with AS and general populations retrieved through Medline and cross-reference search. RESULTS: We observed that the general prevalence of HLA-B27 among Jordanians is 2.4%; while the reported prevalence ranges between 2% and 5% among major Arab populations. The prevalence of HLA-B27 among patients with AS is 71% in Jordan and 73% in Qatar, while the reported prevalence from pooled published data from various Arab populations is 64%. CONCLUSION: From these data one can conclude that HLA-B27 is present in about 2% to 5% among major Arab populations and that its prevalence in Arab patients with AS is closer to 70%. |
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Authors:
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Khader N Mustafa; Mohammed Hammoudeh; Muhammad Asim Khan |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-1 |
Journal Detail:
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Title: The Journal of rheumatology Volume: - ISSN: 0315-162X ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the University of Jordan, Division of Rheumatology, Department of Internal Medicine, Jordan University Hospital, Amman, Jordan; Rheumatology Unit, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar; and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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