| HLA-B maternal-fetal genotype matching increases risk of schizophrenia. | |
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MedLine Citation:
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PMID: 16960807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Schizophrenia and human leukocyte antigen (HLA) matching between couples or between mothers and offspring have independently been associated with prenatal/obstetric complications, including preeclampsia and low birth weight. Here, we report the results of a family-based candidate-gene study that brings together these two disparate lines of research by assessing maternal-fetal genotype matching at HLA-A, -B, and -DRB1 as a risk factor of schizophrenia. We used a conditional-likelihood modeling approach with a sample of 274 families that had at least one offspring with schizophrenia or a related spectrum disorder. A statistically significant HLA-B maternal-fetal genotype-matching effect on schizophrenia was demonstrated for female offspring (P=.01; parameter estimate 1.7 [95% confidence interval 1.22-2.49]). Because the matching effect could be associated with pregnancy complications rather than with schizophrenia per se, these findings are consistent with the neurodevelopmental hypothesis of schizophrenia and with accumulating evidence that the prenatal period is involved in the origins of this disease. Our approach demonstrates how genetic markers can be used to characterize the biology of prenatal risk factors of schizophrenia. |
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Authors:
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Christina G S Palmer; Hsin-Ju Hsieh; Elaine F Reed; Jouko Lonnqvist; Leena Peltonen; J Arthur Woodward; Janet S Sinsheimer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-08-15 |
Journal Detail:
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Title: American journal of human genetics Volume: 79 ISSN: 0002-9297 ISO Abbreviation: Am. J. Hum. Genet. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-08 Completed Date: 2006-10-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370475 Medline TA: Am J Hum Genet Country: United States |
Other Details:
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Languages: eng Pagination: 710-5 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, CA 90095, USA. cpalmer@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Genotype HLA Antigens / immunology HLA-A Antigens / genetics HLA-B Antigens / genetics* HLA-DR Antigens / genetics Humans Male Nuclear Family Pregnancy Pregnancy Complications / genetics, immunology Risk Factors Schizophrenia / genetics*, physiopathology Sex Characteristics |
| Grant Support | |
ID/Acronym/Agency:
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GM53275/GM/NIGMS NIH HHS; MH066001/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen |
| Comments/Corrections | |
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