Document Detail

HLA-B maternal-fetal genotype matching increases risk of schizophrenia.
MedLine Citation:
PMID:  16960807     Owner:  NLM     Status:  MEDLINE    
Schizophrenia and human leukocyte antigen (HLA) matching between couples or between mothers and offspring have independently been associated with prenatal/obstetric complications, including preeclampsia and low birth weight. Here, we report the results of a family-based candidate-gene study that brings together these two disparate lines of research by assessing maternal-fetal genotype matching at HLA-A, -B, and -DRB1 as a risk factor of schizophrenia. We used a conditional-likelihood modeling approach with a sample of 274 families that had at least one offspring with schizophrenia or a related spectrum disorder. A statistically significant HLA-B maternal-fetal genotype-matching effect on schizophrenia was demonstrated for female offspring (P=.01; parameter estimate 1.7 [95% confidence interval 1.22-2.49]). Because the matching effect could be associated with pregnancy complications rather than with schizophrenia per se, these findings are consistent with the neurodevelopmental hypothesis of schizophrenia and with accumulating evidence that the prenatal period is involved in the origins of this disease. Our approach demonstrates how genetic markers can be used to characterize the biology of prenatal risk factors of schizophrenia.
Christina G S Palmer; Hsin-Ju Hsieh; Elaine F Reed; Jouko Lonnqvist; Leena Peltonen; J Arthur Woodward; Janet S Sinsheimer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-08-15
Journal Detail:
Title:  American journal of human genetics     Volume:  79     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2006-10-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  710-5     Citation Subset:  IM    
Department of Psychiatry and Biobehavioral Sciences, University of California-Los Angeles, Los Angeles, CA 90095, USA.
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MeSH Terms
HLA Antigens / immunology
HLA-A Antigens / genetics
HLA-B Antigens / genetics*
HLA-DR Antigens / genetics
Nuclear Family
Pregnancy Complications / genetics,  immunology
Risk Factors
Schizophrenia / genetics*,  physiopathology
Sex Characteristics
Grant Support
Reg. No./Substance:
0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen

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