Document Detail

The HLA-B gene and Hashimoto disease in Han Chinese children: a case-control and family-based study.
MedLine Citation:
PMID:  23020308     Owner:  NLM     Status:  In-Data-Review    
Hashimoto disease (HD) is an autoimmune thyroid disease resulting from complex interactions between genetic and environmental factors. The human leukocyte antigen (HLA) gene has been established to be involved in the susceptibility to HD. We aim to investigate the associations between HLA-B alleles and Han Chinese children with HD by both case-control and family-based studies. A total of 108 unrelated children with HD, 380 unrelated healthy controls, 58 trios of affected patients and their parents, and 75 trios of unaffected siblings and their parents were recruited. HLA-B genotyping was performed by polymerase chain reaction and detected with a sequence-specific oligonucleotide probes system. We found that B*46:01 allele (OR = 2.31, 95% CI 1.60-3.34, P(c) = 9.99 × 10(-5) ) and carrier (OR = 3.28, 95% CI 2.10-5.11, P(c) = 1.35 × 10(-6) ) were associated with HD risk. Transmission/disequilibrium test further confirmed an overtransmission of the B*46:01 (OR 2.55, 95% CI 1.36-6.10, P = 6.5 × 10(-3) ). The findings were similar in females when stratified by gender. In conclusion, our results clearly identify that HLA-B*46:01 confers susceptibility to HD in Han Chinese children. Further studies with larger children cohort are required to confirm the role of B*46:01 in the development of HD.
C-Y Huang; T-Y Chang; C-C Chu; F-S Lo; W-H Ting; C-H Lin; Y-L Wu; S-Y Chu; S-C Chang; W-F Chen; C-L Lin; W-S Lin; Y-J Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  80     ISSN:  1399-0039     ISO Abbreviation:  Tissue Antigens     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  431-6     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.
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