Document Detail


HLA-B alleles associated with the B15 serologically defined antigens.
MedLine Citation:
PMID:  9455497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cells expressing HLA molecules in the B15 family were identified by serologic typing in routine testing of volunteer donors of various ethnic backgrounds for a bone marrow registry. DNA sequencing was used to identify HLA-B15 alleles associated with each serologic type and to examine the diversity within the B15 antigen family. Alleles which appeared predominantly in each B15 serologic cluster included: B15 with no defined serologic subdivision (B*1501), B62 (B*1501), B63 (B*1516, B*1517), B75 (B*1502, B*1521), and B76/77 (B*1513). Other B*15 alleles were also found associated with the serotypes and some of these alleles (e.g., B*1501 and B*1516) were found in two or more serologic clusters illustrating the complexity of this family. The B15 unsplit and B75 groups were the most complex exhibiting 16 and 7 alleles, respectively, within each serotype. Five new B*15 alleles (B*1530, B*1531, B*1533, B*1534, B*1535) and 5 other new HLA-B alleles (B*38022, B*3910, B*4010, B*51012, and B*5108) were also identified.
Authors:
N Steiner; J Ng; J Bush; R J Hartzman; L Johnston-Dow; C K Hurley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Human immunology     Volume:  56     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:    1997 Aug-Sep
Date Detail:
Created Date:  1998-02-11     Completed Date:  1998-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  84-93     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, Georgetown University Medical School, Washington, DC 20007, USA.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Antigenic Variation
Cross Reactions
HLA-B Antigens / genetics*
Histocompatibility Testing
Humans
Sequence Analysis, DNA
Serologic Tests*
Chemical
Reg. No./Substance:
0/HLA-B Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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