| HLA A, B and DR typing in idiopathic dilated cardiomyopathy: a search for immune response factors. | |
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MedLine Citation:
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PMID: 6585136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several autoimmune diseases have been associated with increased frequencies of various histocompatibility antigen (HLA) types that may be linked to immune response genes. Idiopathic dilated cardiomyopathy (IDC) has been proposed as a disease with autoimmune features, but HLA associations have not been evaluated. We performed HLA typing in 37 consecutive patients with IDC. Patients with habitual alcoholism were excluded. Results showed that no single HLA type could account for most cases; IDC is a genetically heterogeneous disease. However, uneven distributions were noted for certain types. Haplotype frequency of B27 was 0.145 in patients vs 0.033 in 5,726 local control subjects (p less than 0.001). Other A and B frequencies (except A2) were evenly distributed. HLA DR typing also revealed differences. The DR4 locus was present in 54% (19 of 35) of patients, vs 32% (26 of 82) of blood bank control subjects (p less than 0.02). The associated relative risk of DR4 was 2.2 and the etiologic fraction 0.29. Sex, disease chronicity, functional class, ejection fraction and biopsy evidence of myocarditis did not distinguish DR4-positive from DR4-negative patients, but they were older (54 +/- 12 vs 42 +/- 14 years, p less than 0.02). Of note, 68% were positive for DR4 or B27, or both. HLA DR6Y was underrepresented; it was present in 9% (3 of 35) of patients, vs 26% (21 of 82) of control subjects (p less than 0.04). The relative risk of DR6Y was 0.27 and the preventive fraction 0.19. These associations will require independent confirmation. However, they suggest that genetically determined immune response factors associated with HLA loci may play a role in pathogenesis in certain patients with IDC. |
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Authors:
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J L Anderson; J F Carlquist; J R Lutz; C W DeWitt; E H Hammond |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 53 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-05-21 Completed Date: 1984-05-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1326-30 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System
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immunology Adult Aged Cardiomyopathy, Dilated / immunology* Female HLA Antigens / immunology* HLA-A Antigens HLA-B Antigens HLA-DR Antigens Haploidy Heart Failure / immunology* Histocompatibility Antigens Class II / immunology* Histocompatibility Testing / methods* Humans Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System; 0/HLA Antigens; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-DR Antigens; 0/Histocompatibility Antigens Class II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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