| Human leukocyte antigen-A, -B, -C, -DRB1 allele and haplotype frequencies in Americans originating from southern Europe: contrasting patterns of population differentiation between Italian and Spanish Americans. | |
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MedLine Citation:
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PMID: 20974205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High-resolution DNA sequencing was used to identify the human leukocyte antigen (HLA) -A, -B, -C, and -DRB1 alleles found in 552 individuals from the United States indicating Southern European (Italian or Spanish) heritage. A total of 46 HLA-A, 80 HLA-B, 32 HLA-C, and 50 DRB1 alleles were identified. Frequent alleles included A*02:01:01G (allele frequency = 0.26 in Italian Americans and 0.22 in Spanish Americans); B*07:02:01G (Italian Americans allele frequency = 0.11); B*44:03 (Spanish Americans allele frequency = 0.07); C*04:01:01G and C*07:01:01G (allele frequency = 0.13 and 0.16, respectively, in Italian Americans; 0.15 and 0.12, respectively, in Spanish Americans); and DRB1*07:01:01 (allele frequency = 0.12 in each population). The action of balancing selection was inferred at the HLA-B and -C loci in both populations. The A*01:01:01G-C*07:01:01G-B*08:01:01G-DRB1*03:01:01 haplotype was the most frequent A-C-B-DRB1 haplotype in Italian Americans (haplotype frequency = 0.049), and was the second most frequent haplotype in Spanish Americans (haplotype frequency = 0.021). A*29:02:01-C*16:01:01-B*44:03-DRB1*07:01:01 was the most frequent A-C-B-DRB1 in Spanish Americans (haplotype frequency = 0.023), and was observed at a frequency of 0.015 in Italian Americans. Pairwise F'(st) values measuring the degree of differentiation between these Southern European American populations as well as European and European American populations suggest that Spanish Americans constitute a distinct subset of the European American population, most similar to Mexican Americans, whereas Italian Americans cannot be distinguished from the larger European American population. |
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Authors:
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Steven J Mack; Bin Tu; Ruyan Yang; Carly Masaberg; Jennifer Ng; Carolyn Katovich Hurley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-23 |
Journal Detail:
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Title: Human immunology Volume: 72 ISSN: 1879-1166 ISO Abbreviation: Hum. Immunol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-17 Completed Date: 2011-06-29 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 144-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Children's Hospital Oakland Research Institute, Oakland, California, USA. sjmack@chori.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles European Continental Ancestry Group Gene Frequency / genetics* Genetics, Population HLA-A Antigens / genetics*, immunology HLA-B Antigens / genetics*, immunology HLA-C Antigens / genetics*, immunology HLA-DR Antigens / genetics*, immunology Haplotypes / genetics* Hispanic Americans Homozygote Humans Italy / ethnology Leukocytes / immunology Linkage Disequilibrium / genetics, immunology Registries Sequence Analysis, DNA United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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U01AI067068/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DRB1*01:02:03 antigen; 0/HLA-A Antigens; 0/HLA-B Antigens; 0/HLA-C Antigens; 0/HLA-DR Antigens |
| Comments/Corrections | |
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