Document Detail


HLA-A, B, Bf three point association of 1,072 haplotypes in a German population.
MedLine Citation:
PMID:  545746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Altogether 1,072 HLA-A, B, Bf haplotypes in 536 parents of 268 German families were analyzed by gene and haplotype counting in order to investigate the two and three point association of HLA-A and B antigens with Bf alleles. In agreement with previously published data (Albert et al. 1975, Bender et al. 1977) significant positive linkage disequilibria were found for HLA-A3 and BfF, B7 and BfS, B8 and BfS, Bw35 and BfF, whereas significant negative Delta values appeared to exist for HLA-A3 and BfS, B7 and BfF, B8 and BfF, B12 and BfS, as well as Bw35 and BfS. Significant positive three point Delta values were found for the following haplotypes: HLA-A11, Bw35, BfS, HLA-Aw23, Bw35, BfS, HLA-A28, B12, BfS, HLA-A2, B17, BF, HLA-A3, Bw35, BfF, HLA-Aw24, b12, BfF and HLA-A29, B12, BfF. According to the large number of comparisons performed calculating the level of significance of the three point associations, these data have to be corroborated by further investigation. The three point Delta values, obtained by calculation from the patients' phenotypes differed markedly from those results obtained by haplotype counting.
Authors:
J Bertrams; M P Baur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  14     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-07-26     Completed Date:  1980-07-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  317-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alleles*
Female
Gene Frequency
Genotype
Germany, West
HLA Antigens / genetics*
Haploidy*
Humans
Linkage (Genetics)*
Male
Phenotype
Chemical
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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