Document Detail


HL-A antigens in psoriasis with special reference to the clinical type, age of onset, exacerbations after respiratory infections and occurrence of arthritis.
MedLine Citation:
PMID:  1211846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HL-A typing was performed in a series of 125 patients with common psoriasis, 12 patients with flexural psoriasis, 16 patients with erythrodermic psoriasis and 16 patients with generalized pustular psoriasis, and compared with typing in a control population. The HL-A antigens 13 and 17 were significantly increased in patients with common psoriasis and erythrodermic psoriasis. HL-A 17 was also found in two of the 16 patients with generalized pustular psoriasis. Neither HL-A 13 nor 17 was increased in patients with flexural psoriasis. It is suggested that flexular psoriasis might be genetically distinct from common psoriasis. TY was increased in patients with common psoriasis. The increase of HL-A 13, 17 and TY was most marked in patients with onset of psoriasis before the age of 40 years. HL-A 13 was found in 38 per cent of the 40 patients with infection-related exacerbations of psoriasis, but only in 17 per cent (p = 0.012) of the remaining 129 patients. HL-A 27 was found in 58 per cent of the 26 patients with sacro-iliitis and in 27 per cent of the 41 patients with peripheral arthritis without sacro-iliitis, but only in eight per cent of the 102 non-arthritic patients (p less than 0.001) and p less than 0.01, respectively).
Authors:
J Karvonen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of clinical research     Volume:  7     ISSN:  0003-4762     ISO Abbreviation:  Ann. Clin. Res.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-03-20     Completed Date:  1976-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0220042     Medline TA:  Ann Clin Res     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  301-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Arthritis / complications*
Female
HLA Antigens* / isolation & purification
Histocompatibility Antigens*
Histocompatibility Testing
Humans
Male
Middle Aged
Phenotype
Psoriasis / etiology,  immunology*
Respiratory Tract Infections / complications*
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Histocompatibility Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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