Document Detail


HIV type 1 genetic diversity in Moyale, Mandera, and Turkana based on env-C2-V3 sequences.
MedLine Citation:
PMID:  19102688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genetic diversity of HIV-1 subtypes circulating in three districts of northern Kenya, i.e., Turkana, Mandera, and Moyale, was studied. DNA sequences encoding a portion of the env-C2-V3 region of the virus were amplified by PCR and sequenced directly. One hundred and fifty-nine samples were successfully sequenced in the env-C2-V3 region and analyzed. From the analysis, 57% were subtype A1, 27% were subtype C, 9% were subtype D, and the remaining 7% were unclassified. This study showed that HIV-1 subtype A1 was the dominant subtype in circulation in this region, though there was a significant percentage of HIV-1 subtype C in circulation there.
Authors:
Samoel A Khamadi; Raphael W Lihana; D L Mwaniki; Joyceline Kinyua; Nancy Lagat; Jane Y Carter; Hiroshi Ichimura; Isao Oishi; Fredrick A Okoth; Washington Ochieng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  24     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-23     Completed Date:  2009-01-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1561-4     Citation Subset:  IM; X    
Affiliation:
Kenya Medical Research Institute, Nairobi, Kenya.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY952815;  AY952818;  AY952819;  AY952824;  AY952825;  AY952826;  AY952827;  AY952828;  AY952829;  AY952835;  AY952836;  AY952837;  AY952838;  AY952840;  AY952841;  AY952842;  AY952843;  AY952844;  AY952845;  AY952846;  AY952847;  AY952848;  AY952849;  AY952850;  AY952851;  AY952852;  AY952853;  AY952854;  AY952855;  AY952856;  AY952857;  DQ155149;  DQ155150;  DQ155151;  DQ155152;  DQ155153;  DQ155154;  DQ155155;  DQ155156;  DQ155157;  DQ155158;  DQ155159;  DQ155160;  DQ155161;  DQ155162;  DQ155163;  DQ155164;  DQ155165;  DQ155166;  DQ155167;  DQ155168;  DQ155169;  DQ155170;  DQ155171;  DQ155172;  DQ155173;  DQ155174;  DQ155175;  DQ155176;  DQ155177;  DQ155178;  DQ155179;  DQ155180;  DQ155181;  DQ155182;  DQ155183;  DQ155184;  DQ155185;  DQ155186;  DQ155187;  DQ155188;  DQ155189;  DQ155190;  DQ155191;  DQ155192;  DQ155193;  DQ155194;  DQ155195;  DQ155196;  DQ155197;  DQ155198;  DQ155199;  DQ155200;  DQ155201;  DQ155202;  DQ155203;  DQ155204;  DQ155205;  DQ155206;  DQ155207;  DQ155208;  DQ155209;  DQ155210;  DQ155211;  DQ155212;  DQ155213;  DQ155214;  DQ155215;  DQ155216;  DQ155217;  DQ155218;  DQ155219;  DQ155220;  DQ155221;  DQ155222;  DQ155223;  DQ155224;  DQ155225;  DQ155226;  DQ155227;  DQ155228;  DQ155229;  DQ155230;  DQ155231;  DQ155232;  DQ155233;  DQ155234;  DQ155235;  DQ155236;  DQ155237;  DQ155238;  DQ155239;  DQ155240;  DQ155241;  DQ155242;  DQ155243;  DQ155244;  DQ155245;  DQ155246;  DQ155247;  DQ155248;  DQ155249;  DQ155250;  DQ155251;  DQ155252;  DQ155253;  DQ155254;  DQ155255;  DQ155256;  DQ155257;  DQ155258;  DQ155259;  DQ155260;  DQ155261;  DQ155262;  DQ155263;  DQ155264;  DQ155265;  DQ155266;  DQ155267;  DQ155268;  DQ155269;  DQ155270;  DQ155271;  DQ155272;  DQ155273;  DQ155274;  DQ155275;  DQ155276;  DQ155277;  DQ155278;  DQ155279;  DQ155280;  DQ155281;  DQ155282
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MeSH Terms
Descriptor/Qualifier:
Child
Cluster Analysis
DNA, Viral / chemistry,  genetics
Female
Genetic Variation*
Genotype
HIV Infections / epidemiology*,  virology*
HIV-1 / classification*,  genetics*,  isolation & purification
Humans
Kenya / epidemiology
Molecular Epidemiology
Molecular Sequence Data
Polymerase Chain Reaction
Proviruses / genetics
Sequence Analysis, DNA
env Gene Products, Human Immunodeficiency Virus / genetics*
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/env Gene Products, Human Immunodeficiency Virus

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