Document Detail

HIV transmission and primary drug resistance.
MedLine Citation:
PMID:  16736948     Owner:  NLM     Status:  MEDLINE    
Transmission of HIV viruses harboring resistance mutations is already a major concern in developed countries, with the potential to impact on therapeutic strategies. Several factors influence the transmission of such viruses, including viral replication fitness and transmission fitness, although behavioral characteristics must also be considered. Rates of transmission of specific mutations are related to therapeutic strategies. Reports of the transmission of multidrug-resistant viruses should alarm the medical community. An additional concern is the use of monotherapy with nevirapine for the prevention of mother-to-child transmission of HIV in developing countries as this practice selects for resistance to nonnucleoside reverse transcription inhibitors and could limit future therapeutic options of both the mothers and infected children. HIV treatment guidelines have evolved, shifting from more aggressive to more conservative approaches. This change of strategy has had a direct impact on the prevalence of drug-resistant virus in the population and the transmission of resistant viral species.
Dan Turner; Mark A Wainberg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  AIDS reviews     Volume:  8     ISSN:  1139-6121     ISO Abbreviation:  AIDS Rev     Publication Date:    2006 Jan-Mar
Date Detail:
Created Date:  2006-06-01     Completed Date:  2006-06-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101134876     Medline TA:  AIDS Rev     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  17-23     Citation Subset:  IM    
AIDS Center, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
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MeSH Terms
Anti-Retroviral Agents / therapeutic use*
Developing Countries
Drug Resistance, Multiple, Viral / genetics*
Drug Therapy, Combination
HIV Infections / congenital,  transmission*
HIV-1 / drug effects*
Infectious Disease Transmission, Vertical / prevention & control
Pregnancy Complications, Infectious
Reverse Transcriptase Inhibitors / therapeutic use
Reg. No./Substance:
0/Anti-Retroviral Agents; 0/Reverse Transcriptase Inhibitors

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