Document Detail


HIV testing and antiretroviral treatment strategies for prevention of HIV infection: impact on antiretroviral drug resistance.
MedLine Citation:
PMID:  21929723     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
"Test and treat" is a strategy in which widespread screening for human immunodeficiency virus (HIV) is followed by immediate antiretroviral therapy for those testing positive, thereby potentially reducing infectiousness in larger cohorts of infected patients. However, there is a concern that test and treat could lead to increased levels of transmissible drug-resistant HIV, especially if viral load and/or drug resistance is not routinely monitored. Reviews of the existing literature show that up to now, even in the absence of laboratory tests, drug resistance has not created major problems in sub-Saharan Africa. Here we discuss the current evidence for the effectiveness of a preventive test and treat approach and the challenges and implications for daily clinical practice and public health.
Authors:
Brooke E Nichols; Charles A B Boucher; David A M C van de Vijver
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-19
Journal Detail:
Title:  Journal of internal medicine     Volume:  -     ISSN:  1365-2796     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 The Association for the Publication of the Journal of Internal Medicine.
Affiliation:
Department of Virology, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands.
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