Document Detail


HIV-related ocular microangiopathic syndrome and color contrast sensitivity.
MedLine Citation:
PMID:  8206718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Color vision deficits in patients with acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) disease were reported, and a retinal pathogenic mechanism was proposed. The purpose of this study was to evaluate the association of color vision deficits with HIV-related retinal microangiopathy. METHODS: A computer graphics system was used to measure protan, deutan, and tritan color contrast sensitivity (CCS) thresholds in 60 HIV-infected patients. Retinal microangiopathy was measured by counting the number of cotton-wool spots, and conjunctival blood-flow sludging was determined. Additional predictors were CD4+ count, age, time on aerosolized pentamidine, time on zidovudine, and Walter Reed staging. The relative influence of each predictor was calculated by stepwise multiple regression analysis (inclusion criterion; incremental P value = < 0.05) using data for the right eyes (RE). The results were validated by using data for the left eyes (LE) and both eyes (BE). RESULTS: The only included predictors in multiple regression analyses for the RE were number of cotton-wool spots (tritan: R = .70; deutan: R = .46; and protan: R = .58; P < .0001 for all axes) and age (tritan: increment of R [Ri] = .05, P = .002; deutan: Ri = .10, P = .004; and protan: Ri = .05, P = .002). The predictors time on zidovudine (Ri = .05, P = .002) and Walter Reed staging (Ri = .03, P = .01) were additionally included in multiple regression analysis for tritan LE. The results for deutan LE were comparable to those for the RE. In the analysis for protan LE, the only included predictor was number of cotton-wool spots. In the analyses for BE, no further predictors were included. The predictors Walter Reed staging and CD4+ count showed a significant association with all three criteria in univariate analysis. Additionally, tritan CCS was significantly associated with conjunctival blood-flow sludging. CONCLUSION: CCS deficits in patients with HIV disease are primarily associated with the number of cotton-wool spots. Results of this study are in accordance with the hypothesis that CCS deficits are in a relevant part caused by neuroretinal damage secondary to HIV-related microangiopathy.
Authors:
S A Geier; G Hammel; J R Bogner; U Kronawitter; T Berninger; F D Goebel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  35     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3011-21     Citation Subset:  IM; X    
Affiliation:
Augenklinik, Klinikum Innenstadt der Ludwig-Maximilians-Universit?t, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications,  physiopathology
Adult
Color Perception Tests
Color Vision Defects / etiology,  physiopathology*
Contrast Sensitivity / physiology*
HIV Infections / complications,  physiopathology*
HIV-1*
Humans
Male
Middle Aged
Prospective Studies
Retinal Diseases / complications
Retinal Vessels / pathology,  physiopathology*
Syndrome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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