| HIV protease inhibitor therapy reverses neutrophil apoptosis in AIDS patients by direct calpain inhibition. | |
| | |
MedLine Citation:
|
PMID: 16528469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The reduction of neutrophils apoptosis is one of the main non-virological effects of protease inhibitor (PI) therapy. We explore here whether this may be due to the cross-inhibition of calpain, an important non-virological target of PI in vitro. We found that the high basal level of neutrophils apoptosis in AIDS patients is strictly related to an increased intracellular calpain activity. Both alterations disappear after PI treatment, with apoptosis and calpain going back to normal levels after 3 months of PI therapy, independently of a proficient antiviral effect. PI drugs exerted a similar antiapoptotic and anticalpain effects on neutrophils in ex vivo experiments: strikingly, the effects were mimicked by commercially available calpain inhibitors. This study shows, for the first time, that apoptosis of neutrophils in AIDS patients is mediated by calpain, and that neutrophil survival in PI treated AIDS patients is a non virological effect due to calpain inhibition. |
| | |
Authors:
|
M Lichtner; F Mengoni; C M Mastroianni; I Sauzullo; R Rossi; M De Nicola; V Vullo; L Ghibelli |
Related Documents
:
|
8243619 - How problems evolve and dissolve: integrating narrative and strategic concepts. 17990379 - Leisure time physical activity prevents accumulation of central fat in hiv/aids subject... 1920469 - Psychological treatment of erectile dysfunction in men without partners: outcome result... 20236129 - Mtor inhibitor-associated dermatologic and mucosal problems. 9865209 - Combination therapy of resistant warts in a patient with aids. 3057459 - The aids clinical trials unit experience: clinical research and antiviral treatment. 18232849 - Simultaneous solution to dark matter and flavor problems of supersymmetry. 10560759 - Sequential ram-based neural networks: learnability, generalisation, knowledge extractio... 18284099 - A collaborative model for community action against methamphetamine. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Apoptosis : an international journal on programmed cell death Volume: 11 ISSN: 1360-8185 ISO Abbreviation: Apoptosis Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-06-09 Completed Date: 2006-08-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9712129 Medline TA: Apoptosis Country: United States |
Other Details:
|
Languages: eng Pagination: 781-7 Citation Subset: IM |
Affiliation:
|
Department of Infectious and Tropical Diseases, La Sapienza University, Viale del Policlinico Roma, 155, 00161, Rome, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acquired Immunodeficiency Syndrome
/
drug therapy* Adult Apoptosis / drug effects* Benzoxazines Calpain / antagonists & inhibitors* Case-Control Studies Caspase 3 Caspases / metabolism Cells, Cultured Female HIV Protease Inhibitors / pharmacology, therapeutic use* Humans Indinavir / pharmacology, therapeutic use Kinetics Leukocytes, Mononuclear / cytology Male Neutrophils / drug effects* Oxazines / pharmacology, therapeutic use Proteasome Endopeptidase Complex / metabolism Zidovudine / pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Benzoxazines; 0/HIV Protease Inhibitors; 0/Oxazines; 150378-17-9/Indinavir; 154635-17-3/efavirenz; 30516-87-1/Zidovudine; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/Calpain; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases; EC 3.4.25.1/Proteasome Endopeptidase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gross anatomical, CT and MRI analyses of the buccal fat pad with special emphasis on volumetric vari...
Next Document: Translocation of AIF in the human and rat striatum following protracted haloperidol, but not clozapi...