| HIV model incorporating differential progression for treatment-naive and treatment-experienced infectives. | |
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MedLine Citation:
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PMID: 19566119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We formulate an HIV/AIDS deterministic model which incorporates differential infectivity and disease progression for treatment-naive and treatment-experienced HIV/AIDS infectives. To illustrate our model, we have applied it to estimate adult HIV prevalence, the HIV population, the number of new infectives and the number of AIDS deaths for Botswana for the period 1984 to 2012. It is found that the prevalence peaked in the year 2000 and the HIV population is now decreasing. We have also found that under the current conditions, the reproduction number is Rc approximately 13, which is less than the 2004 estimate of Rc approximately equal 4 by [11] and [13]. The results in this study suggest that the HAART program has yielded positive results for Botswana. |
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Authors:
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Esther Chigidi; Edward M Lungu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mathematical biosciences and engineering : MBE Volume: 6 ISSN: 1547-1063 ISO Abbreviation: Math Biosci Eng Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-01 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197794 Medline TA: Math Biosci Eng Country: United States |
Other Details:
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Languages: eng Pagination: 427-50 Citation Subset: IM |
Affiliation:
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University of Botswana, Gaborone, Botswana. chigidie@mopipi.ub.bw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antiretroviral Therapy, Highly Active / standards* Basic Reproduction Number Computer Simulation Disease Progression HIV / immunology* HIV Infections / drug therapy, epidemiology, immunology*, virology Humans Incidence Middle Aged Models, Immunological* Prevalence Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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