Document Detail


HIV infection and dementia in older adults.
MedLine Citation:
PMID:  16619159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus (HIV) infection in older patients is becoming increasingly common as seropositive individuals live longer because of long-term antiretroviral treatment. Simultaneously, the development and expression of dementia among HIV-infected patients is evolving in the era of highly active antiretroviral therapy (HAART) and immune reconstitution. How long-term HAART interacts with chronic HIV infection and advanced age with regard to cognition is not fully understood. This article provides an overview of HIV cognitive impairment as it relates to aging and presents some emerging issues in the field. Particular emphasis is placed on describing the changing landscape of HIV-related cognitive impairment and discussing possible concerns regarding the long-term effects of antiretroviral treatment. A brief discussion of potential adjunctive therapies to reduce cognitive symptoms associated with HIV infection in older individuals is provided.
Authors:
Victor Valcour; Robert Paul
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-04-13
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  42     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-08-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1449-54     Citation Subset:  IM    
Affiliation:
Hawaii AIDS Clinical Research Program and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA. Vvalcour@hawaii.edu
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MeSH Terms
Descriptor/Qualifier:
AIDS Dementia Complex / epidemiology*
Acquired Immunodeficiency Syndrome / complications*,  drug therapy,  epidemiology
Adult
Aged
Aging
Antiretroviral Therapy, Highly Active
HIV Infections / complications*,  drug therapy,  epidemiology
Humans
Middle Aged
United States / epidemiology
Viremia / prevention & control
Grant Support
ID/Acronym/Agency:
1U54NS43049/NS/NINDS NIH HHS; 5U01 A134853//PHS HHS; K23MH065857/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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