Document Detail


HIV infection affects parietal-dependent spatial cognition: evidence from mental rotation and hierarchical pattern perception.
MedLine Citation:
PMID:  18085869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human immunodeficiency virus (HIV) in the asymptomatic phase of the infection impairs some aspects of cognition, but little is known about how visuospatial functions are affected. In the present study, performance on tasks of mental rotation and hierarchical pattern perception was investigated in 14 HIV-positive men and 12 age- and education-matched HIV-negative men. Processes related to mental rotation of objects and hands were impaired in HIV-positive participants as compared to the HIV-negative group. The HIV-positive group was also impaired on hierarchical pattern perception of local targets under global biasing conditions. Consistent with these results, the HIV-positive participants showed impaired performance on standard clinical neuropsychological tests of visuospatial function. These findings indicate that the detrimental effects of HIV on cognition appear even in asymptomatic individuals and affect diverse visuospatial functions that depend upon the integrity of parietal brain regions.
Authors:
Pernille J Olesen; Haline E Schendan; Melissa M Amick; Alice Cronin-Golomb
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  121     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1163-73     Citation Subset:  IM    
Affiliation:
Department of Women and Child Health, Astrid Lindgren's Children's Hospital, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Brain Mapping
Case-Control Studies
Female
HIV Infections / pathology*,  physiopathology*
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Neuropsychological Tests
Parietal Lobe / physiopathology*
Pattern Recognition, Visual / physiology*
Photic Stimulation / methods
Problem Solving
Psychomotor Performance / physiology*
Space Perception / physiology*
Grant Support
ID/Acronym/Agency:
AG005914/AG/NIA NIH HHS

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