| HIV disease progression: depression, stress, and possible mechanisms. | |
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MedLine Citation:
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PMID: 12893105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is much interest in whether depression and stress may explain the wide variability in the disease course of patients infected with human immunodeficiency virus (HIV). This article summarizes the large body of evidence examining whether depression and stress may have an impact on immune- and disease-related parameters in HIV disease. Furthermore, we review what is known about the underlying biological mechanisms of HIV disease, such as alterations in glucocorticoids and catecholamines, which may help explain these psychoimmune relationships. Our review of the literature finds substantial evidence that chronic depression and stressful events may affect HIV disease progression. We know little, however, regarding the biological mechanisms that may account for these relationships. More research is warranted to investigate how depression and stress might impact HIV disease progression and what types of interventions might mitigate the negative impact of chronic depression and trauma. |
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Authors:
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Jane Leserman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Biological psychiatry Volume: 54 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-01 Completed Date: 2003-09-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 295-306 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catecholamines
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metabolism Depression / complications*, immunology, metabolism* Disease Progression Glucocorticoids / metabolism HIV Infections / immunology, metabolism*, psychology Humans Stress, Psychological / complications*, immunology, metabolism* Substance P / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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MH-33127/MH/NIMH NIH HHS; MH-44618/MH/NIMH NIH HHS; P30-HD37260/HD/NICHD NIH HHS; RR-00046/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Glucocorticoids; 33507-63-0/Substance P |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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