Document Detail

HIV disease progression: depression, stress, and possible mechanisms.
MedLine Citation:
PMID:  12893105     Owner:  NLM     Status:  MEDLINE    
There is much interest in whether depression and stress may explain the wide variability in the disease course of patients infected with human immunodeficiency virus (HIV). This article summarizes the large body of evidence examining whether depression and stress may have an impact on immune- and disease-related parameters in HIV disease. Furthermore, we review what is known about the underlying biological mechanisms of HIV disease, such as alterations in glucocorticoids and catecholamines, which may help explain these psychoimmune relationships. Our review of the literature finds substantial evidence that chronic depression and stressful events may affect HIV disease progression. We know little, however, regarding the biological mechanisms that may account for these relationships. More research is warranted to investigate how depression and stress might impact HIV disease progression and what types of interventions might mitigate the negative impact of chronic depression and trauma.
Jane Leserman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Biological psychiatry     Volume:  54     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2003-09-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-306     Citation Subset:  IM    
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.
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MeSH Terms
Catecholamines / metabolism
Depression / complications*,  immunology,  metabolism*
Disease Progression
Glucocorticoids / metabolism
HIV Infections / immunology,  metabolism*,  psychology
Stress, Psychological / complications*,  immunology,  metabolism*
Substance P / metabolism
Grant Support
Reg. No./Substance:
0/Catecholamines; 0/Glucocorticoids; 33507-63-0/Substance P

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