Document Detail

HIV and chemokine binding to red blood cells--DARC matters.
MedLine Citation:
PMID:  18621004     Owner:  NLM     Status:  MEDLINE    
A mutation in the Duffy antigen (DARC) that abrogates receptor expression and gives profound protection against some malaria species has become almost universal in African populations. He et al. (2008) show that this polymorphism also leads to significantly increased susceptibility to HIV-1 infection but, paradoxically, to prolonged survival in HIV-1-infected subjects.
Robert T Walton; Sarah L Rowland-Jones
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Cell host & microbe     Volume:  4     ISSN:  1934-6069     ISO Abbreviation:  Cell Host Microbe     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-09-02     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101302316     Medline TA:  Cell Host Microbe     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-5     Citation Subset:  IM    
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MeSH Terms
Chemokines / metabolism*
Disease Susceptibility*
Duffy Blood-Group System / biosynthesis*,  genetics
Erythrocytes / virology*
HIV / physiology*
Models, Biological
Polymorphism, Genetic*
Receptors, Cell Surface / biosynthesis*,  genetics
Grant Support
MC_U190092710//Medical Research Council
Reg. No./Substance:
0/Chemokines; 0/DARC protein, human; 0/Duffy Blood-Group System; 0/Receptors, Cell Surface
Comment On:
Cell Host Microbe. 2008 Jul 17;4(1):52-62   [PMID:  18621010 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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